FB2026_02 , released June 18, 2026
Allele: Dmel\rodH4.8
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General Information
Symbol
Dmel\rodH4.8
Species
D. melanogaster
Name
FlyBase ID
FBal0014638
Feature type
allele
Associated gene
Dmel\rod
Associated Insertion(s)
Doc{}rodH4.8
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Scaerou et al., 1999)
Progenitor genotype
Associated Insertion(s)
Doc{}rodH4.8
Cytology
Description

Doc insertion in an intron.

(Scaerou et al., 1999)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      chromatin & mitotic anaphase

      (Williams and Goldberg, 1994)

      chromatin & mitotic telophase

      (Williams and Goldberg, 1994)

      nuclear chromosome & mitotic anaphase

      (Williams and Goldberg, 1994)
      Detailed Description
      Statement
      Reference

      Incomplete sister chromatid separation during mitosis. Transmission rate of Dp(1;f)J21A through females to progeny is 28%, rod mutations cause a mild increase in transmission. mei-S3321 ord1 double mutant has no effect Dp(1;f)J21A transmission in males.

      (Cook et al., 1997)

      Strong allele. Lagging chromatids are often observed during anaphase in larval brain cells. Nuclear bridging by strands of chromatin during anaphase/telophase is also common.

      (Williams and Goldberg, 1994)

      % abnormal anaphases: 20.2 % homozygous viable: 25 Mutants show mitotic abnormalities in larval neuroblasts; there is a high frequency of both aneuploid cells and abnormal anaphase figures, with lagging chromatids, anaphase bridges and stretched chromatid arms. Abnormal chromosome behavior also occurs in the second meiotic anaphase in male meiosis, although motile sperm are produced. All surviving homozygous females and 90% of surviving homozygous males are sterile and have roughened eyes, sparse abdominal bristles and notched wings.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The dramatically increased length of the prometaphase/metaphase interval and increase in both mitotic index and metaphase:anaphase ration that is seen in Lis-1G10.14/Lis-1k13209 neuroblasts is not seen if they are also homozygous for rodH4.8, although the centrosome and spindle assembly defects still remain.

      (Siller et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      rodH4.8 is rescued by rod+tC3L9

      (Scaerou et al., 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Does not contain a P-element at the rod locus despite being isolated in a PM hybrid dysgenesis screen.

      (Scaerou et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rodH4.8
      (Pham et al., 2019, Roubinet et al., 2017, Tsankova et al., 2017, Roth et al., 2015, Siller et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)