FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\run29
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General Information
Symbol
Dmel\run29
Species
D. melanogaster
Name
FlyBase ID
FBal0014874
Feature type
allele
Associated gene
Dmel\run
Associated Insertion(s)
Carried in Construct
Also Known As
runYP17, runtYP17, runt29
Key Links
Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Gergen and Wieschaus, 1986)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have weak segmentation defects. The A2/A3 denticle belts appear curved due to a deletion of the lateral edges between the belts. Deletion of naked cuticle between the A4/A5 and A6/A7 denticles is also seen. Defects in the projection of the lch1 neurons are seen in stage 15 embryos.

      (Kaminker et al., 2001)

      Segmentation defect is more severe at higher temperatures. The temperature sensitive period of females doubly heterozygous for run29 and sisA- is extremely short and occurs within the first 2-3 hours of development, during the syncytial blastoderm stage and some of cellularisation. Mutations causes masculinization of triploid intersexes (2X;3A).

      (Torres and Sanchez, 1992)

      run29 embryos shifted to the restrictive temperature after the cellular blastoderm stage have wild-type segmentation.

      (Duffy et al., 1991)

      intermediate hypomorph temperature-sensitive

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      run29 is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gugunspecified

      (Zhang et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      run29 is rescued by runt14.5

      (Duffy et al., 1991)
      Comments

      Mutant phenotype can be rescued by P-element mediated introduction of runt14.5 at 18oC but no survivors are recovered at 29oC.

      (Butler et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Wieschaus.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (17)