FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Scr5
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General Information
Symbol
Dmel\Scr5
Species
D. melanogaster
Name
FlyBase ID
FBal0015281
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Also Known As
Scrw22
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Sivanantharajah and Percival-Smith, 2009, Pattatucci et al., 1991)
Mutagen
ethyl methanesulfonate
(Pattatucci et al., 1991, Lewis et al., 1980)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)
Description

Amino acid replacement: A288T.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: G862A.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,841,319..6,841,319 [-]
Nucleotide change:

G6841319A

Reported nucleotide change:

G862A

Amino acid change:

A288T | Scr-PA; A288T | Scr-PB; A288T | Scr-PD; A288T | Scr-PE; A288T | Scr-PF

Reported amino acid change:

A288T

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous and Scr5/Df(3R)WIN3 males have no sex comb bristles on the prothoracic leg.

      The number of nuclei in the salivary glands of Scr5/Df(3R)WIN3 larvae is not significantly different from normal.

      Scr5/Df(3R)WIN3 and Scr5/Scr13A flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls.

      (Sivanantharajah and Percival-Smith, 2009)

      Prothoracic to mesothoracic, pronotal to mesonotal and labial to maxillary transformations. Polyphasic semi-lethality.

      (Pattatucci et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Scr4/Scr5, pb5/pb1 has visible | homeotic phenotype

      (Abzhanov et al., 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pb1 Scr5/pb5 Scr4 flies show transformation of the proboscis into the antenna. The transformation varies from thick and shortened aristae with claws and pulvillae to apparently complete antennae with aristae, third and second antennal segments bearing characteristic bristles.

      (Abzhanov et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Wakimoto.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      EfW22
      (Lewis et al., 1980)
      Scr5
      (Jordan et al., 2002)
      Scr5
      (Sivanantharajah and Percival-Smith, 2009)
      ScrEfW22
      (Shroff et al., 2007)
      Scrw22
      (Pattatucci et al., 1991, Hazelrigg and Kaufman, 1983)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)