FlyBase Allele Report: Dmel\sd[11]

General Information

Symbol

Dmel\sd¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015357

Feature type

allele

Associated gene

Dmel\sd

Associated Insertion(s)

Carried in Construct

Also Known As

sd^31H

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Williams et al., 1993)

Mutagen

ethyl methanesulfonate

(Katzen and Bishop, 1996, Katzen, 1990)

Progenitor genotype

Cytology

Description

Amino acid replacement refers to the sd E21 isoform. The protein encoded by the sd E7 isoform appears to be unaffected in this mutant.

(Srivastava et al., 2004)

Amino acid replacement: R143K.

(Srivastava et al., 2004)

Nucleotide substitution: G?A.

(Srivastava et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:15,820,474..15,820,474 [+]

Nucleotide change:

G15820474A

Reported nucleotide change:

G?A

Amino acid change:

Reported amino acid change:

R143K

(Srivastava et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

head | P-stage

(Campbell et al., 1991)

wing

(Srivastava et al., 2004)

wing (with sd^ETX4)

(Srivastava et al., 2004)

wing | P-stage

(Campbell et al., 1991)

wing margin (with sd^ETX4)

(Srivastava et al., 2004)

Detailed Description

Statement

Reference

sd¹¹ homozygous mutant embryos do not display any significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

(Keder et al., 2015)

sd¹¹/sd^ETX4 flies have a scalloped wing phenotype, with the loss of most of the wing blade tissue and erosion of the wing margin. About 30% of heterozygotes show notching of the wing.

(Srivastava et al., 2004)

Severe pupal wing defects.

(Williams et al., 1993)

At the late lethal stage individuals exhibit gross morphological head abnormalities and vestigal like pupal wings. Heterozygotes with viable sd alleles exhibit an extreme wing phenotype.

(Campbell et al., 1991)

pupal lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sd¹³

(Srivastava et al., 2004)

sd^ETX4

(Srivastava et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9372

w^* sd¹¹/FM7i, P{ActGFP}JMR3

Notes on Origin

Discoverer

Katzen.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

em31

(Katzen and Bishop, 1996)

sd¹¹

(Keder et al., 2015)

sd^31H

(Srivastava et al., 2004, Campbell et al., 1991)

sd^31h

(Williams et al., 1993)

sd^EM31

(Katzen, 1990)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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