FB2026_02 , released June 18, 2026
Allele: Dmel\shakB6
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General Information
Symbol
Dmel\shakB6
Species
D. melanogaster
Name
FlyBase ID
FBal0015579
Feature type
allele
Associated gene
Dmel\shakB
Associated Insertion(s)
Carried in Construct
Also Known As
E81
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Perrimon et al., 1989, Lifschytz and Falk, 1968)
diethyl sulfate
(Lifschytz and Falk, 1968)
Progenitor genotype
Cytology
Description

Mutation in the lethal and neural common exons. Amino acid replacement: C140@. Nucleotide substitution: TGA to TGT.

(Krishnan et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:20,776,156..20,776,156 [-]
Nucleotide change:

T20776156A

Reported nucleotide change:

A?T

Amino acid change:

C151term | shakB-PA; C140term | shakB-PC; C311term | shakB-PD; C95term | shakB-PE; C71term | shakB-PF; C156term | shakB-PG; C156term | shakB-PH; C156term | shakB-PI

Reported amino acid change:

C140term

(Krishnan et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The DLMs do not respond to brain shocks and the TTMs respond only occasionally and then with a longer than normal latency.

      (Krishnan et al., 1995)

      Abnormal electrophysiological phenotype. Homozygous flies exhibit uncoordinated leg movements under ether anaesthesia and do not jump to a light off stimulus. Heterozygotes are fully viable but exhibit some neuronal defects.

      (Baird et al., 1990)

      Homozygous germline clones display no maternal effect.

      (Perrimon et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      shakB15

      (Munoz and Cook, 2004.4.7)
      Comments

      Fails to complement shakB3.

      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lifschytz.

      Comments
      Comments

      shakB alleles exhibit a complex pattern of complementation.

      (Baird et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      E81
      (Krishnan et al., 1995, Lifschytz and Falk, 1969, Lifschytz and Falk, 1968)
      PasE81
      (Baird et al., 1990)
      l(1)E81
      (Munoz and Cook, 2004.4.7)
      shakB6
      shakBE81
      (Perrimon et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)