FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\enspt
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General Information
Symbol
Dmel\enspt
Species
D. melanogaster
Name
spermatheca
FlyBase ID
FBal0016052
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

Amino acid change is located within a serine-rich region, in which Ser325, Ser340 and Thr341 have been suggested as targets of Protein Kinase C.

(Kato et al., 2022)

Amino acid replacement: S325C.

(Kato et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,526,698..11,526,698 [-]
Nucleotide change:

A11526698T

Amino acid change:

S325C | en-PA; S325C | en-PB

Reported amino acid change:

S325C

Comment:

A Ser325Cys mutation was reported. Additional unreported nucleotide substitutions and indels were observed in the mutant.

(Kato and Itoh, 2022.9.8)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Temperature sensitive phenotype that affects spermathecae. Heterozygotes with en1 and hemizygotes display the en and spermatheca phenotypes at 25oC.

      (Chase and Baker, 1995)

      At 28oC females exhibit two spermatheca but with fused end parts of the ducts. At 25oC females have one single duct with one spermatheca of enlarged size. At 18oC females have one duct with 3 branches, each bearing a spermatheca. Temperature sensitive period is the third larval instar.

      (Hadorn and Graber, 1946)

      At 28oC, female has two spermathecae but ducts partly fused; at 25oC, only one enlarged spermatheca on one duct; at 18oC, a duct with three branches, each bearing a spermatheca. Temperature-sensitive period in third larval instar. Female fertility not greatly affected. RK3.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      enspt/en[+] is a suppressor of increased cell number | oogenesis phenotype of Scer\GAL4C587, Su(var)3-3NIG.17149R

      (Eliazer et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Hadorn, May 1943.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      43e
      (Hadorn and Graber, 1946)
      enspt
      (Kato and Itoh, 2022.9.8, Kato et al., 2022, Eliazer et al., 2014, Rojas-Ríos et al., 2012)
      spt1
      (Chase and Baker, 1995)
      Name Synonyms
      spermatheca
      Secondary FlyBase IDs
        References (9)