FlyBase Allele Report: Dmel\Sry-δ[12]

General Information

Symbol

Dmel\Sry-δ¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0016085

Feature type

allele

Associated gene

Dmel\Sry-δ

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Payre et al., 1994, Crozatier et al., 1992)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G813A. Amino acid replacement: M271I. This is within the third zinc finger.

(Crozatier et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:30,044,288..30,044,288 [+]

Nucleotide change:

G30044288A

Reported nucleotide change:

G813A

Amino acid change:

M270I | Sry-delta-PA

Reported amino acid change:

M271I

Comment:

From GB:X76235

(Crozatier et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Crozatier et al., 1992)

lethal | recessive

(Ferrer et al., 1994, Payre et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

Approximately 60-70% of hemizygous embryos survive, but die as pupae.

(Crozatier et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sry-δ¹² has lethal phenotype, suppressible by Dpse\Sry-delta^tFa

(Ferrer et al., 1994)

Other

Statement

Reference

Dpse\Sry-delta^tFa, Sry-δ¹² has partially lethal phenotype

(Ferrer et al., 1994)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sry-δ¹²/Sry-delta[+] is a suppressor of female germline stem cell phenotype of piwi²

(Smulders-Srinivasan and Lin, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Lethality is largely rescued by one copy of Dpse\Sry-δ^tFa.

(Ferrer et al., 1994)

Complementation and Rescue Data

Rescued by

Sry-δ¹² is rescued by Sry-δ^CH8

(Crozatier et al., 1992)

Sry-δ¹² is rescued by Sry-δ^CH2

(Crozatier et al., 1992)

Comments

Rescued by Sry-δ^CH8 and Sry-δ^CH2.

(Crozatier et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kongsuwan, Vincent, Lengyel and Merriam.

Comments

Introduction of P{sryDB56,ry⁺} causes partial rescue of the mutant phenotype, all derivatives of the head are affected.

(Payre et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sry-δ¹²

δ12

(Ferrer et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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