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General Information
Symbol
Dmel\su(f)13
Species
D. melanogaster
Name
FlyBase ID
FBal0016278
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
su(f)madts
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution within exon 3 causing an amino acid replacement.

restriction map normal

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes are phenotypically wild type at 18oC.

After 3 days at the restrictive temperature of 29oC, follicles do not develop beyond stage 9. The follicle cells gradually degenerate and there is a breakdown in intrafollicular polarity. Cytoplasmic extrusions, consisting either of ooplasm or nurse cell cytoplasm, are seen filling the space between two follicles and the epithelial sheath surrounding the ovariole. Cytoplasmic islands surrounded by membrane and consisting of abnormal cytoplasm containing condensed material or high concentrations of lipids are seen. Clusters of mitochondria and multilamellar bodies are present, and many follicle cell nuclei contain virus-like particles. Finally, follicles devoid of follicle cells fuse to form a tube. The morphology of the 16 cystocytes and mesodermal profollicle cells in the germarium of flies maintained at 29oC for 7 days appears normal.

A cell-autonomous, temperature-sensitive recessive allele. Phenotype similar to that of su(f)12 except that trypan-blue staining provides no evidence of cell death resulting from heat shock at stages of development in which such treatment induces leg duplications. Authors postulate that su(f)12 discs developmentally impaired by heat shock, giving rise to observed abnormalities. Temperature-sensitive period from late second instar until two hours into pupariation. Shifts from 22oC to 29oC during the first larval instar leads to inability to pupariate; shifts between 112 and 164 h arrests adult development; shifts within the first six hours after the temperature for lethality removes bristles from the tergites. Gynandromorphs and somatic clones formed normally at permissive temperatures, but are not observed in adults produced at 29oC. Ecdysteroid level of larvae raised at 29oC are less than one-tenth that of wild type; pupariation can be induced by ecdysterone supplementation (Klose, Gateff, Emmerich and Beikirch, 1980). temperature-sensitive lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

su(f)13 is a suppressor of phenotype of f1

Additional Comments
Genetic Interactions
Statement
Reference

Homozygotes survive and suppress the f1 phenotype at intermediate temperatures.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Jurgens.

Comments
Comments

At 30oC su(f)13 complements su(f)26, su(f)5, su(f)2 and su(f)4 and fails to complement su(f)19, su(f)16-185, su(f)28, su(f)27, su(f)25, su(f)3, su(f)6 and su(f)12. The complementation pattern of su(f)13 and su(f)12 is the same. The allelic state of z has no effect on complementation behaviour.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
l(1)madts
su(f)13
Name Synonyms
Secondary FlyBase IDs
    References (6)