FB2025_05 , released December 11, 2025
Allele: Dmel\swa4
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General Information
Symbol
Dmel\swa4
Species
D. melanogaster
Name
FlyBase ID
FBal0016667
Feature type
allele
Associated gene
Dmel\swa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Stephenson and Mahowald, 1987, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

The lesion reported for swa4 in FBrf0174546 is different from that reported in FBrf0127311.

(Pokrywka et al., 2004)

Amino acid replacement: H283N.

(Pokrywka et al., 2004)

Amino acid replacement: G503D.

(Schnorrer et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,364,569..6,364,569 [-]
Nucleotide change:

C6364569A

Amino acid change:

H283N | swa-PA

Reported amino acid change:

H283N

Comment:

FBrf0127311 and FBrf0174546 report different sites of mutation for swa4. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Pokrywka et al., 2004)
point_mutation
X:6,363,820..6,363,820 [-]
Nucleotide change:

G6363820A

Amino acid change:

G503D | swa-PA

Reported amino acid change:

G503D

Comment:

FBrf0127311 and FBrf0174546 report different sites of mutation for swa4. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Schnorrer et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from swa4/Df(1)JF5 females mated to wild-type males often show cuticle defects, ranging from embryos without cuticle and lacking any sign of development (61%), through embryos with a reduction in the number of abdominal segments to embryos that have 8 abdominal segments, with normal or nearly normal abdominal morphology. The most commonly represented cuticular class is embryos that have 4-6 abdominal segments, with the arrangement of segments usually abberant, with segments often fused (42%).

      (Pokrywka et al., 2004)

      Most eggs laid by homozygous females develop.

      (Tearle and Nusslein-Volhard, 1987)

      Embryonic defects detectable at gastrulation. Eggs are laid that collapse on deposition.

      (Mohler and Carroll, 1984)

      maternal-effect lethal strong allele female-sterile.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      swa[+]/swa4 is a suppressor of female sterile | semidominant phenotype of αTub67C3

      (Pokrywka et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      swa[+]/swa4 is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of αTub67C3

      (Pokrywka et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Approximately 68.5% of embryos derived from swa4/+;αTub67C3/+ females hatch to apparently normal embryos, compared to approximately 44.8% of embryos derived from αTub67C3/+ females. Approximately 23.2% of embryos derived from swa4/+;67C3/+ female flies arrest development before cuticle formation, compared to approximately 37.2% of embryos derived from αTub67C3/+ female flies. Approximately 8.3% of embryos derived from swa4/+;αTub67C3/+ female flies arrest development after cuticle formation but before hatching, compared to approximately 18% in embryos derived from αTub67C3/+ females.

      (Pokrywka et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mohler.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      fs(1)13C-82
      (Stephenson and Mahowald, 1987)
      fs(1)13C82
      fs(1)M4413C82
      (Mohler and Carroll, 1984)
      swa13C-82
      (Pokrywka et al., 2004)
      swa4
      swa82
      (Schnorrer et al., 2000, Tearle and Nusslein-Volhard, 1987)
      sww13C-82
      (Pokrywka et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)