FB2026_02 , released June 18, 2026
Allele: Dmel\swa6
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General Information
Symbol
Dmel\swa6
Species
D. melanogaster
Name
FlyBase ID
FBal0016669
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
swa384, 384
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: Q422term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C6364064T

Amino acid change:

Q422term | swa-PA

Reported amino acid change:

Q422term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos derived from swa6/Df(1)JF5 females mated to wild-type males often show cuticle defects, ranging from embryos without cuticle and lacking any sign of development (62%), through embryos with a reduction in the number of abdominal segments to embryos that have 8 abdominal segments, with normal or nearly normal abdominal morphology. The most commonly represented cuticular class in embryos that develop is embryos that have 8 abdominal segments, with normal or nearly normal abdominal morphology (69%).

Defects in actin organisation are first detectable at about stage 10 in mutant oocytes. Small irregularly-shaped actin aggregates and actin spheres are seen below the actin-rich cortical layer. Most of the actin spheres are "hollow", having an actin-rich surface and an actin-poor core. About 30% of stage 10 oocytes have a relatively mild mutant phenotype in which a few clumps and spheres are limited to the anterior subcortical layer of the oocyte. About 10% of stage 10 egg chambers have a larger number of aggregates and spheres which are distributed throughout the oocyte and fused actin spheres. About 60% of oocytes between stages 11 to 14 have detectable defects in actin organisation. In these abnormal oocytes, actin spheres about 3-5μm in diameter are uniformly distributed from the subcortical layer into deeper central cytoplasm. The spheres are more numerous in later stages of oogenesis and a larger fraction of them are hollow. Occasional "double" spheres consisting of two spheres fused at their surface are seen. Tiny actin granules are visible on the surface of the spheres.

Excess of irregularly shaped internal chromatin masses, and chromatin condensation is asynchronous. During preblastoderm and early blastoderm cleavages lagging chromosomes during anaphase are common. Pregastrula and gastrula embryos exhibit nuclear defects, an excess of irregularly shaped internal chromatin masses, blastoderm nuclei are non-uniform in size and chromatin condensation and asynchronous in the cell cycle.

No surviving offspring: defects in cephalopharyngeal apparatus. Many embryos have abdominal segment fusions or deletions.

maternal-effect lethal female-sterile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

swa[+]/swa6 is a suppressor of female sterile | semidominant phenotype of αTub67C3

Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Approximately 60.3% of embryos derived from swa6/+;αTub67C3/+ females hatch to apparently normal embryos, compared to approximately 44.8% of embryos derived from αTub67C3/+ females. Approximately 35.1% of embryos derived from swa6/+;67C3/+ females arrest development before cuticle formation, compared to approximately 37.2% of embryos derived from αTub67C3/+ females. Approximately 4.6% of embryos derived from swa6/+;αTub67C3/+ females arrest development after cuticle formation but before hatching, compared to approximately 18% in embryos derived from αTub67C3/+ females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Complete penetrance of phenotype.

Mutant protein enters the nuclei of mutant embryos normally.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (8)