FlyBase Allele Report: Dmel\Tl[rv1]

General Information

Symbol

Dmel\Tl^rv1

Species

D. melanogaster

Name

FlyBase ID

FBal0016843

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

Also Known As

Tl^1-RXA, Tl^I-RXA, Tl^RxA, Tl^l-RXA, Toll^1-RXA

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tearle and Nusslein-Volhard, 1987)

loss of function allele

(Lemaitre et al., 1997)

Mutagen

X ray

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Progenitor genotype

Tl¹

(Anderson et al., 1985)

Cytology

Polytene chromosomes normal.

(Anderson et al., 1985)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary immunodeficiency disease

CEA

(Zanette et al., 2013)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates hematologic cancer

modeled by mxc^G46

(Remillieux-Leschelle et al., 2002)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response (with Tl^r3)

(Chen et al., 2010, Taylor and Kimbrell, 2007)

abnormal immune response | adult stage (with Tl^r3)

(Alarco et al., 2004)

abnormal immune response | conditional (with Tl^r3)

(Zanette et al., 2013)

abnormal neuroanatomy | adult stage (with Tl^r3)

(Zhang et al., 2024)

decreased rate of adult locomotory behavior (with Tl^r3)

(Zhang et al., 2024)

increased cell death | adult stage (with Tl^r3)

(Zhang et al., 2024)

Phenotype Manifest In

abdomen | conditional (with Tl^r3)

(Zanette et al., 2013)

adult brain (with Tl^r3)

(Zhang et al., 2024)

adult dopaminergic neuron | decreased number (with Tl^r3)

(Zhang et al., 2024)

embryonic/larval hemocyte (with Tl^r3)

(Remillieux-Leschelle et al., 2002)

head | conditional (with Tl^r3)

(Zanette et al., 2013)

hemolymph | conditional (with Tl^r3)

(Zanette et al., 2013)

thorax | conditional (with Tl^r3)

(Zanette et al., 2013)

Detailed Description

Statement

Reference

Tl^r3/Tl^rv1 flies do not exhibit significantly different survival rates in response to Staphylococcus aureus infection, as compared to control flies.

(Ben-Ami et al., 2013)

Tl^r3/Tl^rv1 flies infected with Pythium insidiosum show significantly lower survival rates than wild-type. As evidenced by histopathological studies, injected P. insidiosum zoospores germinate rapidly in fly hemolymph to form hyphae that subsequently disseminate and invade the thorax, abdomen and head of the mutants. No histopathological alterations are found in wild-type flies after P. insidiosum infection.

(Zanette et al., 2013)

Mutant flies show no significant difference in mortality compared to wild-type flies after infection with either Providencia rettgeri or Providencia burhodogranariea.

(Galac and Lazzaro, 2011)

Tl^r3/Tl^rv1 flies show a reduced survival rate compared to control flies after infection with either S. aureus or A. fumigatus.

(Chen et al., 2010)

Infection with the S. aureus 'ItaS' mutant causes earlier death than infection with its parent RN4220 strain in Tl^rv1/Tl^r3 flies, similar to the findings with wild type flies.

(Hashimoto et al., 2009)

Adult females transheterozygous for Tl^r3/Tl^rv1 display increased sensitivity to infection with various strains of Candida albicans: the survival rate of infected flies is significantly decreased compared to wild-type. Tl^r3/Tl^rv1 also show significantly higher post-infection fungal load, which unlike in wild-type flies progressively increases with time when infected with a wild-type strain of C. albicans.

(Alarco et al., 2004)

The ability of Tl^r2/Tl^rv1 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

(Sorrentino et al., 2004)

The concentration of circulating hemocytes in Tl^rv1/Tl^r3 larvae is reduced compared to controls.

(Remillieux-Leschelle et al., 2002)

Level of Drs induction of bacterially challenged Tl^r3/Tl^rv1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Inducibility of all antimicrobial genes by bacterial challenge in imd¹/imd¹; Tl^r3/Tl^rv1 double mutants is severely reduced. Septic injury (pricking with a needle under nonsterile conditions) or infection with E.coli does not noticeably affect Tl^r3/Tl^rv1 survival, infection with A.fumigatus results in death after 2-3 days clearly associated with uncontrolled fungal development. 40% homozygous double mutant flies survive after septic injury but only a few individuals survive 3 days postinfection with E.coli. Infection of Tl^r3/Tl^rv1 mutants with A.fumigatus causes 8% survival 3 days postinfection, infection with E.coli causes survival rates similar to wild type.

(Lemaitre et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tl^r3/Tl^rv1 is an enhancer of abnormal immune response phenotype of Rel^E20

(De Gregorio et al., 2002)

NOT Enhancer of

Statement

Reference

Tl^rv1 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

Tl^rv1 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Tl^rv1 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

Tl^r3/Tl^rv1 is a suppressor of embryonic/larval hemocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

NOT Suppressor of

Statement

Reference

Tl^rv1 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Tl^r3/Tl^rv1 is a non-suppressor of lamellocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

Tl^r3/Tl^rv1 is a non-suppressor of embryonic/larval plasmatocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of spz⁴ or Tl^rv1/Tl^r3 enhances the susceptibility of Rel^E20 mutants to E.coli infection, but has no affect on susceptibility to A.fumigatus injection or natural infection by B.bassiana.

(De Gregorio et al., 2002)

The increased concentration of circulating hemocytes seen in mxc^G43 larvae is suppressed by Tl^rv1/Tl^r3, but the numbers of podocytes and lamellocytes are still increased in the double mutants compared to wild type.

(Remillieux-Leschelle et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

Tl^1-RXA

(Chen et al., 2010, Chen et al., 2010, Buchon et al., 2009, Peng et al., 2005, Alarco et al., 2004, Sorrentino et al., 2004, Riede, 2001, Hedengren et al., 2000, Manfruelli et al., 1999, Levashina et al., 1998, Nicolas et al., 1998, Lemaitre et al., 1997, Lemaitre et al., 1996, Tearle and Nusslein-Volhard, 1987)

Tl^I-RXA

(da Costa et al., 2023, Wurster et al., 2022, Dalla Lana et al., 2021, Pippi et al., 2021, Wurster et al., 2020, Wurster et al., 2019, Chamilos et al., 2009)

Tl^RV1

(Taylor and Kimbrell, 2007)

Tl^RXA

(Hof-Michel et al., 2024, Chamilos et al., 2008, Taylor and Kimbrell, 2007, Remillieux-Leschelle et al., 2002, Anderson et al., 1985)

Tl^RxA

(Bach et al., 2003)

Tl^l-RXA

(Zhang et al., 2024, Zanette et al., 2013, De Gregorio et al., 2002)

Tl^l-RxA

(Ben-Ami et al., 2013)

Tl^rv1

(Araki et al., 2019, Louradour et al., 2017, Hashimoto et al., 2009)

Toll 1-^RxA

(Galac and Lazzaro, 2011)

Toll^1-RXA

(Kanoh et al., 2021, Uttenweiler-Joseph et al., 1998)

Toll^1-rxa

(Hirata et al., 2025)

Toll^1RXA

(Brun et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (39)

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