FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trx2
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General Information
Symbol
Dmel\trx2
Species
D. melanogaster
Name
FlyBase ID
FBal0017166
Feature type
allele
Associated gene
Dmel\trx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Suppressor of the Dlw1/Dlw+ ventral to dorsal wing transformation.

      (Tiong et al., 1995)

      Recessive; lethal in homozygotes or with trx3 or trxD.

      (Lindsley and Zimm, 1992)

      The recessive embryonic lethal trx2 fails to complement trx1, trx3, or trxD, either for the transformation phenotype or for lethality. Trans-heterozygotes of trx2 with another allele or with a deficiency for the locus show weak expression of the trx homeotic phenotype and about 40-50% pupal lethality. Since the lethal mutations are cell viable, trx2/trx3 clones have been induced by mitotic recombination in trx2/trx3; Dp(3;1)kar5l, trx+ flies. The clones produced showed transformations of the antenna, eye, head capsule and proboscis, bristle abnormalities in the legs, vein and bristle abnormalities in the wings and transformations of haltere to wing tissue and of genital to thoracic tissue; mutant clones in abdominal segments one to seven were not found.

      (Ingham, 1985)

      The recessive embryonic lethal trx2 fails to complement trx1, trx3, or trxD, either for the transformation phenotype or for lethality. Trans-heterozygotes of trx2 with another allele or with a deficiency for the locus show weak expression of the trx homeotic phenotype and about 40-50% pupal lethality. Since the lethal mutations are cell viable, trx2/trx3 clones have been induced by mitotic recombination in trx2/trx3; Dp(3;1)kar5l, trx+ flies.

      (Ingham, 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      SceD1/+ ; brm2 trx2/+ triple heterozygotes show transformations of third leg to second leg, having both apical and preapical bristles on the distal tibia of the third leg (which are characteristic of the wild-type second leg). The third leg may also have sternopleural bristles (characteristics of the wild-type second leg).

      (Gildea et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      trx2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)