FlyBase Allele Report: Dmel\trx[3]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\trx³

General Information

Symbol

Dmel\trx³

Species

D. melanogaster

Name

FlyBase ID

FBal0017167

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Breen, 1999)

non-enhancer of variegation, with P{418}e(Pc)84DE^T66.1

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T3

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T13.5

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T26

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T30

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T33.1.24j

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T40

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T42.1

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T43

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T44

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T53.3

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T63

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T69.3

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T72.1

(Fauvarque and Dura, 1993)

non-enhancer of variegation, with P{418}T72.2

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}e(Pc)84DE^T66.1

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T3

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T13.5

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T26

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T30

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T33.1.24j

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T40

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T42.1

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T43

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T44

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T53.3

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T63

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T69.3

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T72.1

(Fauvarque and Dura, 1993)

non-suppressor of variegation, with P{418}T72.2

(Fauvarque and Dura, 1993)

some die during embryonic stage | recessive

(Breen, 1999)

visible | dominant

(Kankel et al., 2004)

visible | dominant | homeotic

(Breen, 1999)

Phenotype Manifest In

abdominal tergite 1

(Breen, 1999)

abdominal tergite 2

(Breen, 1999)

abdominal tergite 3

(Breen, 1999)

adult abdominal segment 4 | ectopic

(Kankel et al., 2004)

adult abdominal segment 5

(Kankel et al., 2004)

(Breen, 1999)

adult thorax | anterior

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

prothoracic segment

(Breen, 1999)

prothoracic segment | ventral

(Breen, 1999)

Detailed Description

Statement

Reference

9.3% of heterozygotes show transformation of segment A5 to A4.

(Kankel et al., 2004)

20.8% of heterozygous adults show at least one transformation phenotype. trx³ may be slightly antimorphic. trx³/trx^Z11 adults occasionally developed small heads, anterior thoracic segments, abnormal antennae with reduced aristae and reduced or absent maxillary palps. They also often develop A1 tergites with dark pigmentation and large Uab-like bristles at their posterior borders. The flies have patches of small bristles in the A2 and A3 tergites that are normally only found in the A1 tergite. Transformation of ventral T1 to ventral T2 is seen, and sternopleural bristles are present on T1.

(Breen, 1999)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

Suppressor of the Dlw¹/Dlw⁺ ventral to dorsal wing transformation.

(Tiong et al., 1995)

Like trx². About 75% of the trx¹/trx³ transheterozygotes are lethals, larval and pupal (Ingham, 1981). recessive; lethal in homozygotes or with trx² or trx^D

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trx³ has visible | dominant | homeotic phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

trx³ has visible | dominant | homeotic phenotype, enhanceable by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

trx³ has visible | dominant | homeotic phenotype, enhanceable by Gug³³³³/Gug[+]

(Kankel et al., 2004)

trx³ has visible | dominant | homeotic phenotype, enhanceable by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

trx³ has adult abdominal segment 4 | ectopic phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

trx³ has adult abdominal segment 4 | ectopic phenotype, enhanceable by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

trx³ has adult abdominal segment 4 | ectopic phenotype, enhanceable by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

trx³ has adult abdominal segment 4 | ectopic phenotype, enhanceable by Gug³³³³/Gug[+]

(Kankel et al., 2004)

trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug³³³³/Gug[+]

(Kankel et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Ingham (1981).

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

trx³

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections