FlyBase Allele Report: Dmel\tx[1]

General Information

Symbol

Dmel\tx¹

Species

D. melanogaster

Name

FlyBase ID

FBal0017319

Feature type

allele

Associated gene

Dmel\tx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Varte et al., 2022, Cook and Carpenter, 2002, Howe et al., 1995)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

A 25 bp deletion leading to a shift in the reading frame at the C-terminus of the tx coding sequence. Thus, the last 20 residues are replaced by 32 disparate residues.

(Varte et al., 2022)

No alteration has been detected in the coding region.

(Egoz-Matia et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:26,448,632..26,448,656 [+]

Comment:

A 25bp deletion starting in residue 365 of @tx. The final 20 amino acids are replaced with 32 novel amino acids.

(Varte et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | adult stage (with tx^KO-mCherry)

(Varte et al., 2022)

abnormal flight | adult stage | recessive

(Varte et al., 2022)

viable

(Howe et al., 1995)

visible

(Egoz-Matia et al., 2011)

visible (with tx¹⁴)

(Egoz-Matia et al., 2011)

visible | adult stage (with tx^ju-1)

(Varte et al., 2022)

visible | adult stage (with tx^KO-mCherry)

(Varte et al., 2022)

visible | adult stage | recessive

(Varte et al., 2022)

Phenotype Manifest In

direct flight muscle motor neuron | conditional

(Varte et al., 2022)

wing

(Varte et al., 2022, Egoz-Matia et al., 2011)

wing (with tx^ju-1)

(Varte et al., 2022)

wing (with tx^KO-mCherry)

(Varte et al., 2022)

wing sensillum

(Egoz-Matia et al., 2011)

wing sensillum (with tx¹⁴)

(Egoz-Matia et al., 2011)

Detailed Description

Statement

Reference

Mutant wings typically have a crease lengthwise and have extra sensory bristles.

tx¹/tx¹⁴ flies have extra sensory bristles on the wing.

(Egoz-Matia et al., 2011)

Homozygous mutants frequently hold out only one wing out and rarely show other wing phenotypes. tx¹/Df animals have strongly outheld wings that are thickened, slightly cupped and occasionally blistered.

(Cook and Carpenter, 2002)

Wings held out at about 75^o from body axis, often arched or wavy, somewhat narrow and dusky. Unable to fly because of shape and posture of wings. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement