FlyBase Allele Report: Dmel\Ubx[abx-2]

General Information

Symbol

Dmel\Ubx^abx-2

Species

D. melanogaster

Name

FlyBase ID

FBal0017514

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

abx²

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Peifer and Bender, 1986, Bender et al., 1983)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)

Description

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

Mutation in downstream control region.

(Irvine et al., 1993)

Deletion internal to Ubx at +47kb with respect to transcription start site (in the major intron).

(Muller and Bienz, 1991)

Deletion of DNA within the abx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Deletion within an intron of the Ubx transcription unit.

(Little et al., 1990)

Deletion of DNA.

(Micol et al., 1990)

1.5kb deletion within the 6.8kb enhancer element located position -82kb to -75kb on the Ubx map.

(Simon et al., 1990)

Deletion from position -79 to -77.5kb of the Ubx locus.

(Peifer and Bender, 1986)

Ubx^abx-2 is associated with a 1.5kb deletion.

(Casanova et al., 1985)

1.5kb deletion from map position -79.5 to -78kb.

(Bender et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | homeotic

(Bender et al., 1983)

visible | recessive

(Simon et al., 1990, Casanova et al., 1985)

Phenotype Manifest In

adult mesothoracic segment

(Casanova et al., 1985)

adult metathoracic segment

(Casanova et al., 1985)

adult metathoracic segment anterior compartment

(Castelli-Gair and Garcia-Bellido, 1990)

haltere

(LaJeunesse and Shearn, 1995, Simon et al., 1990, Peifer and Bender, 1986, Bender et al., 1983)

katepimeron

(Peifer and Bender, 1986)

larval mesothoracic segmental nerve | adult stage

(Teugels and Ghysen, 1985)

larval metathoracic intersegmental nerve | adult stage | dorsal

(Teugels and Ghysen, 1985)

larval metathoracic intersegmental nerve | adult stage | ventral

(Teugels and Ghysen, 1985)

larval metathoracic segmental nerve | adult stage

(Teugels and Ghysen, 1985)

metathoracic leg

(LaJeunesse and Shearn, 1995, Bender et al., 1983)

metathoracic leg | anterior

(Peifer and Bender, 1986)

metathoracic segment | dorsal

(Peifer and Bender, 1986)

Detailed Description

Statement

Reference

Increases the frequency of the trx bithorax-variegated phenotype (partial transformation of T3 to T2, mostly in the anterior compartment) in heterozygous combination with Df(3R)red-P52.

(Castelli-Gair and Garcia-Bellido, 1990)

Transformation of parasegment 5 structures to parasegment 4. Adults display transformation of anterior haltere to anterior wing.

(Simon et al., 1990)

Phenotype shows variable penetrance and expressivity, and erratic specificity.

(Botas et al., 1988)

Ubx¹⁹⁵/Ubx^abx-2 transheterozygotes show extensive transformations of second thoracic leg to first leg structures.

(Weinzierl et al., 1987)

Haltere are transformed to wing and are 3-20% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 4-8 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern.

(Peifer and Bender, 1986)

Variable, often asymmetrical, transformation of T3a toward T2a, and variable transformation of T2p to T1p. Transformation of T2p to T1p is stronger at 17^oC. Flies frequently show a humerus-like structure in the dorsal region, anterior to (and normally some distance from) the transformed mesothorax. Ubx^abx-2 shows a similar but stronger phenotype than Ubx^abx-1.

(Casanova et al., 1985)

Homozygous or hemizygous flies have a number of abnormal transversal fascicles in the CNS; the posterior internal T2, anterior dorsal T3, anterior ventral T3 and posterior dorsal T3 fascicles, and occasionally the internal posterior T3 fascicle are affected.

(Teugels and Ghysen, 1985)

Transformation of anterior third thoracic segment to second thoracic segment.

(Bender et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^abx-2 has phenotype, enhanceable by ash1²⁸

(LaJeunesse and Shearn, 1995)

Ubx^abx-2 has phenotype, enhanceable by ash2¹⁸

(LaJeunesse and Shearn, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygotes with ash1²⁸ exhibit haltere to wing transformation and third to second leg transformation. Double heterozygotes with ash2¹⁸ exhibit haltere to wing transformation.

(LaJeunesse and Shearn, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kerridge.

(Peifer and Bender, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ubx^abx-2

abx²

(Casares et al., 1997, Singh and Brown, 1997, LaJeunesse and Shearn, 1995, Muller and Bienz, 1991, Castelli-Gair and Garcia-Bellido, 1990, Little et al., 1990, Mathog, 1990, Micol et al., 1990, Simon et al., 1990, Botas et al., 1988, Casanova et al., 1988, Babu et al., 1987, Weinzierl et al., 1987, Casanova et al., 1985, Teugels and Ghysen, 1985, Bender et al., 1983)

abx^SK

(Duncan, 2002, Peifer and Bender, 1986)

bx^SK

(Bender et al., 1983)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

Open Close