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General Information
Symbol
Dmel\Ubxbxd-51j
Species
D. melanogaster
Name
FlyBase ID
FBal0017535
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bxd51j
Key Links
Allele class
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Cis-regulatory mutation.

Insertion of a gypsy element.

Gypsy element insertion.

gypsy element insertion into the bxd regulatory region. The direction of transcription of the gypsy element is in the opposite direction to Ubx transcription.

Insertion of gypsy element.

Insertion of a gypsy element. The direction of transcription of the gypsy element is opposite to the direction of transcription of Ubx.

gypsy insertion at map position -17.5kb.

Insertion components
gypsy{}Ubxbxd-51j
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A few double heterozygotes for ash128 at 27oC exhibit haltere to wing transformation. Double heterozygotes for ash218 at 20oC or 27oC do not show homeotic transformations.

Transformation of posterior portion of haltere towards wing, loss of A1 tergite and appearance of T3 legs on A1. Ventral setal belt of A1 is transformed toward that of T3 and ventral pits appear on abdominal segments A1 to A7, inclusive.

Dominant transformation of first abdominal segment towards the third. Individuals carrying abd-A+ and Ubxbxd-51j have the complete abdominal leg phenotype, the phenotype is suppressed by two doses of abd-A.

Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

Ubxbxd-51j/Df(3R)Ubx109 flies show complete loss of the first abdominal tergite, the haltere is enlarged, and there is a band of postnotal tissue in the dorsal third thoracic segment. Approximately 40% of these flies have extra legs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Ubxbxd-51j has phenotype, suppressible by su(Hw)unspecified

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

ssa Ubxbx-3 Ubxbxd-51j hemizygotes do not emerge as imagos. Dissection of late pupae reveals flies have four pairs of legs (Ubxbx-3 Ubxbxd-51j phenotype) and the fourth pair of legs exhibit severe disruption of segmentation and an improvement in the segmentation of the third pair.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The mutant phenotype of bx homozygotes and heterozygotes for different bx alleles can be rescued by Ubxbxd-51j.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (16)