Open Close
General Information
Symbol
Dmel\wapl3
Species
D. melanogaster
Name
FlyBase ID
FBal0018420
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos derived from germline clones usually arrest prior to blastoderm formation but manage to form small patches of cuticle. Brain cells of mutant larvae show defects in heterochromatin organisation. In metaphase figures, the sister chromatids of the major autosomes and of the X chromosome are aligned parallel to each other, instead of the wild-type X- and V- shaped arrangements. The Y and 4th chromosomes are resolved into two distinct sister chromatids, in contrast to wild type. The sister chromatids of all mutant chromosomes are not completely separated but are instead connected by a thread located in the centromeric region. The mitotic index is normal. The chromocenters of polytene chromosomes appear normal. wapl3/In(1)FM7 females show a significant increase in X chromosome nondisjunction compared to control +/In(1)FM7 females. wapl3 has no effect on meiotic exchange.

Lethality occurs during larval and pupal stages. Phenotype of homozygous germ line clones is maternal effect lethal.

L3 larval/pupal boundary lethal exhibit small disk phenotype; homozygous germ-line clones produce zygotes that arrest in preblastoderm stage.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Not rescued by

wapl3 is not rescued by wapltB

wapl3 is not rescued by wapltA

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Lefevre.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)