FB2026_02 , released June 18, 2026
Allele: Dmel\cactSu
Open Close
General Information
Symbol
Dmel\cactSu
Species
D. melanogaster
Name
Suppressor
FlyBase ID
FBal0020002
Feature type
allele
Associated gene
Dmel\cact
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Belvin et al., 1995)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Belvin et al., 1995)
Progenitor genotype
Cytology
Description

Single base pair change in the 5' splice donor of intron six, T to A substitution at the second nucleotide of intron 6. The predicted protein lacks exon 7 of the maternal cact RNA and in its place has 5 amino acids encoded by intron 6.

(Belvin et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,314,449..16,314,449 [-]
Nucleotide change:

T16314449A

Reported nucleotide change:

T?A

Amino acid change:

V478E | cact-PC

Comment:

Single base pair change in the 5' splice donor of intron six, T to A substitution at the second nucleotide of intron 6.

(Belvin et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are fully viable and females produce wild type embryos.

      (Belvin et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cactSu is a suppressor of lethal | dominant | embryonic stage phenotype of Tl4

      (Belvin et al., 1995)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      cactSu is a suppressor of phenotype of eaD3

      (Belvin et al., 1995)

      cactSu is a suppressor of phenotype of spzunspecified

      (Belvin et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mutation suppresses ventralising phenotypes Tl, ea, spz and cact embryos. cactSu/cact+;eaD3/ea+ mothers produced 50% wild type hatching larvae and the remaining 50% unhatched embryos have a wild type cuticular phenotype.

      (Belvin et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      recovered as a dominant suppressor of eaD3

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Able to block signalling from the dorsal ventral pathway. Revertants of the mutation have been isolated that fail to suppress the ventralising phenotype of ea mutations.

      (Belvin et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cactSu
      Name Synonyms
      Suppressor
      (Belvin et al., 1995)
      Secondary FlyBase IDs
        References (3)