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General Information
Symbol
Dmel\eaD3
Species
D. melanogaster
Name
FlyBase ID
FBal0003476
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ea83l
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C15330156T

Reported nucleotide change:

C1177T

Amino acid change:

A325V | ea-PA; A194V | ea-PB

Reported amino acid change:

A325V

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: A325V.

Nucleotide substitution: C1177T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos laid by heterozygous females are moderately ventralised; ventral denticle bands are expanded, dorsolaterally derived structures such as the filzkorper are reduced or absent and the dorsal hairs are almost completely missing. At gastrulation, embryos laid by mutant females invaginate an apparently normal ventral furrow, but initiation of the lateral cephalic furrow is shifted to a more dorsal position and fewer dorsal folds are formed than normal. Embryos laid by eaD3/Df(3R)ea-5022rx1 females are virtually indistinguishable from embryos laid by eaD3/+ females.

All eggs laid by eaD3/ea+ mothers are moderately ventralised.

Ventralized.

Embryos moderately ventralized.

Heterozygous embryos have a moderately ventralized phenotype: denticle belts wider than wild type and dorsolaterally derived filzkorper is absent. Heterozygous females are sterile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

eaD3 has phenotype, suppressible by cactSu

eaD3 has phenotype, suppressible by Tlr1

eaD3 has phenotype, suppressible by Tlr5

eaD3 has phenotype, suppressible by Tlrv13

eaD3 has phenotype, suppressible by Tlrv19

Additional Comments
Genetic Interactions
Statement
Reference

Perivitelline fluid from embryos laid by eaD3 spz4/ea1 spz2 females does not show axis-inducing activity when injected into the perivitelline space of embryos derived from pip1/pip2 females.

cactSu/cact+;eaD3/ea+ mothers produce 50% wild type hatching larvae and the remaining unhatched embryos have a wild type cuticular phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

1 X ray revertant and 4 P revertants recovered

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (9)