FlyBase Allele Report: Dmel\Tl[r1]

General Information

Symbol

Dmel\Tl^r1

Species

D. melanogaster

Name

FlyBase ID

FBal0016836

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

Also Known As

Tl^r26

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tearle and Nusslein-Volhard, 1987)

loss of function allele

(Schneider et al., 1991)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Anderson et al., 1985)

Description

Nucleotide substitution: T2379C. Amino acid replacement: V576A. This mutation is in the extracellular domain of the protein.

(Schneider et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:26,839,580..26,839,580 [+]

Nucleotide change:

T26839580C

Reported nucleotide change:

T2379C

Amino acid change:

V576A | Tl-PB; V576A | Tl-PC; V576A | Tl-PD

Reported amino acid change:

V576A

Comment:

This mutation is in the extracellular domain of the protein.

(Schneider et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | maternal effect | recessive | heat sensitive

(Gerttula et al., 1988)

lethal - all die during embryonic stage | dominant | maternal effect

(Anderson et al., 1985)

some die during embryonic stage | dominant | maternal effect | maternal effect

(Anderson et al., 1985)

Phenotype Manifest In

larval VL3/4 motor neuron | heat sensitive

(Halfon et al., 1995)

larval VO1 motor neuron | heat sensitive

(Halfon et al., 1995)

larval VO2 motor neuron | heat sensitive

(Halfon et al., 1995)

Detailed Description

Statement

Reference

Pupal lethal when heterozygous with the MBT chromosome.

(Riede, 2001)

At 30^oC there are errors in RP motoneuron number at 4 times the frequency seen at 18^oC. The defects are similar to those seen for Tl null mutant combination Df(3R)Tl-X/Df(3R)ro-XB3 or hemizygotes. Loss of innervation of muscle fibers 6 and 7 is due to loss of RP3 motoneuron.

(Halfon et al., 1995)

Incompletely penetrant dominant dorsalization.

(Chasan et al., 1992)

Embryos from homozygous females are strongly dorsalised.

(Schneider et al., 1991)

Dorsalized embryos at the restrictive temperature.

(Gerttula et al., 1988)

Isolated on the basis of a hypomorph dominant dorsalized phenotype. temperature-sensitive for the maternal effect, showing stronger dorsalization of the embryonic pattern at 29^oC than at 18^oC; also temperature-sensitive for viability. TSP for the maternal effect begins slightly before pole cell formation and ends in midsyncytial blastoderm in the offspring of Tl^r7 females. TSP for zygotic viability begins late in embryogenesis and extends into the second larval instar in Tl^r5 and Tl^r6 mutants. recessive

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Tl^r1 is a suppressor of phenotype of ea^D3

(Chasan et al., 1992)

Additional Comments

Genetic Interactions

Statement

Reference

Dominant suppressor of dominant ea ventralizing mutants. Double mutant combinations with ea^D3 and ea^D6 are strongly dorsalized.

(Chasan et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Leaky mutation.

(Anderson et al., 1985)

Demonstrates zygotic haploinsufficiency.

(Halfon et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tl^r1

Tl^r26

(Alpar et al., 2018, Halfon et al., 1995, Chasan et al., 1992, Schneider et al., 1991, Gerttula et al., 1988, Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

r26

(Riede, 2001)

Name Synonyms

Secondary FlyBase IDs

References (8)

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