FlyBase Allele Report: Dmel\Tl[rv13]

General Information

Symbol

Dmel\Tl^rv13

Species

D. melanogaster

Name

FlyBase ID

FBal0016855

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

Also Known As

Tl^5BREQ

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Belvin et al., 1995, Gerttula et al., 1988, Tearle and Nusslein-Volhard, 1987)

loss of function allele

(Lindsley and Zimm, 1992)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Progenitor genotype

Tl²

(Anderson et al., 1985)

Cytology

Polytene chromosomes normal.

(Anderson et al., 1985)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant embryos do not respond to injected purified polarizing activity (spz).

(Schneider et al., 1994)

Incompletely penetrant dominant dorsalization.

(Chasan et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Tl^rv13 is a suppressor of phenotype of ea^D1

(Chasan et al., 1992)

Tl^rv13 is a suppressor of phenotype of ea^D3

(Chasan et al., 1992)

Additional Comments

Genetic Interactions

Statement

Reference

Perivitelline fluid from embryos laid by Tl^rv13 spz⁴/Tl^rv4 spz² females does not show axis-inducing activity when injected into the perivitelline space of embryos derived from pip¹/pip² females. Perivitelline fluid from embryos laid by Tl^rv13/Tl^rv19 females shows polarising activity when injected into the perivitelline space of embryos derived from pip¹/pip² females.

(Chang and Morisato, 2002)

Dominant suppressor of dominant ea ventralizing mutants. Double mutant combinations with ea^D1 are strongly dorsalizing.

(Chasan et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)

Comments

Injection of spz into Tl^- embryos does not cause rapid degradation of cact.

(Belvin et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

5BREQ

(Riede, 2001)

Df(3R)Tl^5BREQ

(Morisato, 2001)

Tl^5B-REQ

(Tearle and Nusslein-Volhard, 1987)

Tl^5BRE

(Roth, 1993)

Tl^5BREQ

(Chang and Morisato, 2002, Misra et al., 1998, Belvin et al., 1995, Morisato and Anderson, 1994, Schneider et al., 1994, Chasan and Anderson, 1993, Chasan et al., 1992, Gerttula et al., 1988, Anderson et al., 1985)

Tl^rv13

Name Synonyms

Tollrv13

(Stein et al., 2010)

Secondary FlyBase IDs

References (16)

Report Sections

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