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General Information
Symbol
Dmel\eaD1
Species
D. melanogaster
Name
FlyBase ID
FBal0003474
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ea5.13
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G15330260A

Reported nucleotide change:

G1281A

Amino acid change:

V360M | ea-PA; V229M | ea-PB

Reported amino acid change:

V360M

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: V360M.

Nucleotide substitution: G1281A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos laid by heterozygous females are either lateralised, developing a cuticle with rings of ventral and lateral denticle bands. At gastrulation, embryos laid by heterozygous females fail to invaginate a ventral furrow and have a widened head fold. Embryos laid by eaD1/Df(3R)ea-5022rx1 females are markedly more elongated and have fewer denticle bands than embryos laid by eaD1/+ females.

Additional dl protein in gain of function dorsal group backgrounds shifts the nuclear dl gradient ventrally.

Lateralized embryos: cuticle is an elongated tube covered with rings of denticles. dpp, zen and twi are only expressed at the poles, only transient expression of sna is seen.

Embryos lateralized.

Embryos have a lateralized phenotype: differentiate rings of ventral denticles around the entire dorso-lateral circumference and do not form the ventrally derived mesoderm. Heterozygous females are sterile.

Dominant allele. Embryos are lateralised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

eaD1 has phenotype, suppressible by Tlrv13

eaD1 has phenotype, suppressible by Tlrv19

Additional Comments
Genetic Interactions
Statement
Reference

Perivitelline fluid from embryos laid by eaD1 spz2/ea4 spz4 females shows axis-inducing activity when injected into the the perivitelline space of embryos derived from pip1/pip2 females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

9 EMS revertants and 2 X ray revertants recovered

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (12)