FB2026_02 , released June 18, 2026
Allele: Dmel\encBB129
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General Information
Symbol
Dmel\encBB129
Species
D. melanogaster
Name
FlyBase ID
FBal0021522
Feature type
allele
Associated gene
Dmel\enc
Associated Insertion(s)
P{lacW}encBB129
Carried in Construct
Also Known As
encBB
Key Links
Allele class

heat sensitive gain of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive gain of function allele

(Hawkins et al., 1996)
Mutagen
P-element activity
(Hawkins et al., 1997, Hawkins et al., 1996)
PM hybrid dysgenesis
(Hawkins and Schupbach, 1992)
Progenitor genotype
Associated Insertion(s)
P{lacW}encBB129
Cytology
Description

P element insertion with the enc locus.

(Hawkins and Schupbach, 1992)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs derived from homozygous females are ventralised, having fused dorsal appendages resulting in a single appendage on the dorsal midline, or lacking dorsal appendages completely. This phenotype is cold-sensitive.

      (Hawkins et al., 1997)

      Homozygous females exhibit defects during oogenesis. Egg chambers either contain twice the normal number of germline cells, are bipolar exhibiting an increase in the number of germline cells and have a defect in the correct positioning of the oocyte or in a small number of cases contain less than 16 germline cells. Phenotype is more severe at 25oC. At 18oC in the egg chambers that have the normal number of nurse cells the oocyte nucleus is enlarged (highly polyploid) and has a roughened appearance.

      (Hawkins et al., 1996)

      Ovaries undergo an extra round of mitosis in the germline to produce egg chambers with an excess number of nurse cells. Some of the egg chambers are also bipolar.

      (Hawkins and Schupbach, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Imprecise excision of the P-element has generated other enc alleles.

      (Hawkins and Schupbach, 1992)

      Δ2-3 induced mobilisation of P{lacW} demonstrates the insertion is responsible for the female sterile phenotype.

      (Hawkins et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      encBB129
      encBB
      (Ohlmeyer and Schupbach, 2003, Van Buskirk et al., 2000, Hawkins et al., 1997, Hawkins et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)