FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gpdh1AT198
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General Information
Symbol
Dmel\Gpdh1AT198
Species
D. melanogaster
Name
FlyBase ID
FBal0029808
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
P{KP}Gpdh1AT198
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Reed and Gibson, 1993)
Mutagen
natural population
(Reed and Gibson, 1993)
Progenitor genotype
Associated Insertion(s)
P{KP}Gpdh1AT198
Cytology
Description

1.15kb insertion of defective (KP) P element in 5' region of Gpdh gene, at nucleotide position 1305, inserted in the same orientation as the Gpdh gene. This KP element is identical in sequence to the two KP elements isolated by Black et al.,(1987, EMBO J 6:4125--4135 ). A T to G substitution unique to this allele was found, also in the 5' untranslated region, at nucleotide position 1267. The sequence GTGCAAAC is found at the insertion site and is repeated at the 3'end of the element.

(Reed and Gibson, 1993)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      The level of Gpdh1 RNA is significantly reduced in the low activity strain Gpdh1AT198.

      (Reed and Gibson, 1993)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Less than 50% activity of glycerol-3-phosphate dehydrogenase compared to normal-activity wild type allele.

      (Reed and Gibson, 1993)

      Homozygous GpdhAT198 flies and GpdhAT198/Df(2L)GpdhA flies have reduced Gpdh enzyme activity compared to wild-type. Slow electrophoretic variant.

      (Gibson et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: Tamar, Tasmania population, 1984.

      (Reed and Gibson, 1993)
      Comments
      Comments

      Isolated from a population in Tamar, Tasmania, in 1984.

      (Gibson et al., 1991)

      See also Gibson et al., 1986, Heredity 56:227--235 , Gibson et al., 1991, Heredity 66:75--82 and Symonds and Gibson, 1992, Biochem. Genet. 30:167--186 .

      (Reed and Gibson, 1993)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gpdh1AT198
      GpdhAT198
      GpdhT198
      (Gibson et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)