FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Psc1433
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General Information
Symbol
Dmel\Psc1433
Species
D. melanogaster
Name
FlyBase ID
FBal0030044
Feature type
allele
Associated gene
Dmel\Psc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Wu and Howe, 1995)

hypomorphic allele - genetic evidence

(Martin and Adler, 1993)
Mutagen
ethyl methanesulfonate
(Martin and Adler, 1993, Lasko and Pardue, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
DQ022537
AAZ20641
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome.

      (Cryderman et al., 1999)

      Lethal over Psc1, shows some degree of viability over deficiencies for the region. Adult survivors of transallelic combinations of "hopeful" alleles show homeotic phenotypes. The wing is often half or less their normal size, bulbous, arched upward and curved inward in the shape of a cashew nut. The posterior compartment of the wing is more severely affected than the anterior compartment. Alula can be reduced or missing, posterior wing margin is missing and the flanking wing blade is eroded. This homeotic phenotype resembles that of the Cbx mutations, and is dominantly enhanced by Su(z)24. Enhances z1 eye color.

      (Wu and Howe, 1995)

      Homozygotes survive to pupae at low frequency.

      (Martin and Adler, 1993)

      Heterozygotes show bristle loss.

      (Lasko and Pardue, 1988)

      recessive semi-lethal dominant bristle loss

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lasko.

      Comments
      Comments

      Weak Psc allele.

      (Adler et al., 1989)

      Member of the "hopeful" class of Psc alleles, i.e. shows some degree of viability in trans to at least one of the "hapless" alleles.

      (Wu and Howe, 1995)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      49Ea2
      (Lasko and Pardue, 1988)
      Psc1433
      (Emmons et al., 2009)
      Psc49Ea-2
      l(2)33
      l(2)49Ea2
      vr14-33
      vr1433
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0009047
      References (8)