FlyBase Allele Report: Dmel\S[X155]

General Information

Symbol

Dmel\S^X155

Species

D. melanogaster

Name

FlyBase ID

FBal0030194

Feature type

allele

Associated gene

Dmel\S

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Heberlein et al., 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Heberlein et al., 1993)

some die during embryonic stage | recessive

(Heberlein et al., 1993)

visible

(Guichard et al., 1999)

Phenotype Manifest In

eye | somatic clone

(Heberlein and Rubin, 1991)

presumptive embryonic/larval central nervous system

(Heberlein et al., 1993)

wing vein | germline clone

(Guichard et al., 1999)

wing vein L2 | germline clone

(Guichard et al., 1999)

wing vein L3 | germline clone

(Guichard et al., 1999)

wing vein L4 | germline clone

(Guichard et al., 1999)

Detailed Description

Statement

Reference

Homozygous mutant clones cause vein-loss phenotypes, sometimes extending a few cells outside the clone boundary. In other cases, vein truncation is rescued within the border of the clone. These reciprocal forms of local cell non-autonomy appear to depend on the shape of the clone, an island of cells tend to take on the vein phenotype associated with the surrounding cells. Homozygous mutant clones on the dorsal side of the wing tend to remove both dorsal and ventral components of the wing vein, however ventral clones generally only affect the ventral components. Homozygous Minute clones reveal that wing veins L1, L2, L3, and L4 are often almost completely eliminated, though for L3, and L4 only the distal halves of the vein are typically affected. The anterior marginal vein L1 is never affected. The overall pattern of vein loss is very similar to rho⁶ clones, though clones lacking S^X155 seem to have slightly stronger vein-loss phenotypes extending more proximally than rho⁶.

(Guichard et al., 1999)

Projection patterns of retinal axons in heterozygous larvae are indistinguishable from wild type.

(Sawamoto et al., 1996)

Clonal analysis of Star alleles shows that the progression of the morphogenetic furrow is delayed and dpp expression was inhibited near the clones.

(Heberlein et al., 1993)

Homozygous clones in the eye are always associated with a scar, surrounded by normal ommatidia of mixed genotype.

(Heberlein and Rubin, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

S^X155 is an enhancer of phenotype of aos^hs.PSa

(Sawamoto et al., 1996)

Suppressor of

Statement

Reference

S^X155, Scer\GAL4^Bx-MS1096 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Bx-MS1096, stet^UAS.cGa

(Guichard et al., 2000)

S^X155/S[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4^Bx-MS1096, rho^UAS.cBa

(Guichard et al., 1999)

S^X155 is a suppressor of wing vein | ectopic | somatic clone phenotype of Scer\GAL4^Bx-MS1096, rho^UAS.cBa

(Guichard et al., 1999)

S^X155/S[+] is a suppressor of phenotype of aos²⁵⁷

(Sawamoto et al., 1996)

S^X155 is a suppressor of retina & axon phenotype of aos²⁵⁷

(Sawamoto et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of S^X155 to stet^Scer\UAS.cGa, Scer\GAL4^Bx-MS1096 flies almost completely suppresses the ectopic vein phenotype seen in these flies.

(Guichard et al., 2000)

Overexpression of rho^Scer\UAS.cBa driven by Scer\GAL4^Bx-MS1096 in S^X155 homozygous clones, produced a S^X155 type phenotype, the rho^Scer\UAS.cBa induced solid wing phenotype is completely suppressed.

(Guichard et al., 1999)

Suppresses the retinal axon phenotype caused by argos²⁵⁷.

(Sawamoto et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Analysis of ommatidia of mixed genotype at the edge of clones in the eye indicates that photoreceptor cells R2, R5 and R8 require the S gene product for normal development, but photoreceptor cells R1, R3, R4, R6 and R7 do not.

(Heberlein and Rubin, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

S^X155

S^x155

(Heberlein and Rubin, 1991)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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