FlyBase Allele Report: Dmel\cas[Δ1]

General Information

Symbol

Dmel\cas^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0030720

Feature type

allele

Associated gene

Dmel\cas

Associated Insertion(s)

Carried in Construct

Also Known As

cas^D1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Zhang et al., 1996)

Mutagen

Delta2-3 transposase

(Zhang et al., 1996, Mellerick et al., 1992)

Progenitor genotype

P{enH+Hox.A}plx^23A

(Zhang et al., 1996, Mellerick et al., 1992)

Cytology

Description

Imprecise excision of the P{enH+Hox.A} element causing deletion of cas sequences.

(Mellerick et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kambadur et al., 1998)

lethal - all die during embryonic stage | recessive

(Mellerick et al., 1992)

some die during embryonic stage | recessive

(Mellerick et al., 1992)

Phenotype Manifest In

presumptive embryonic/larval central nervous system

(Mellerick et al., 1992)

subesophageal zone neuron

(Losada-Pérez et al., 2010)

thoracic neuroblast NB5-6 | increased number

(Baumgardt et al., 2009)

Detailed Description

Statement

Reference

There no SELK neurons observed in cas^Δ1 mutant animals compared to two observed in controls.

(Losada-Pérez et al., 2010)

cas^Δ1/cas^Δ3 mutant larval ventral nerve cords display an increased number of neuroblast 5-6T cells compared to controls. The neuroblast fails to exit the cell cycle at stage 15.

(Baumgardt et al., 2009)

Homozygous embryos fail to exit the egg chambers and show no signs of movement although they are fully developed with normal cuticles and wild type denticle belts. Their CNS network is reduced.

(Mellerick et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

cas^Δ1 is rescued by cas^+tKa

(Kuzin et al., 2012)

Partially rescued by

cas^Δ1 is partially rescued by cas^tKb

(Kuzin et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

H23AΔ1

(Kuzin et al., 2012)

cas^D1

(Díaz-de-la-Peña et al., 2020, Herrero et al., 2014, Benito-Sipos et al., 2010)

cas^H23AΔ1

(Clements et al., 2003)

cas^Δ1

(Bahrampour et al., 2017, Stratmann and Thor, 2017, Gabilondo et al., 2016, Stratmann et al., 2016, Baumgardt et al., 2014, Chang et al., 2013, Losada-Pérez et al., 2013, Ulvklo et al., 2012, Benito-Sipos et al., 2011, Benito-Sipos et al., 2010, Losada-Pérez et al., 2010, Baumgardt et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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