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Citation
Stratmann, J., Gabilondo, H., Benito-Sipos, J., Thor, S. (2016). Neuronal cell fate diversification controlled by sub-temporal action of Kruppel.  eLife 5(): e19311.
FlyBase ID
FBrf0233788
Publication Type
Research paper
Abstract

During Drosophila embryonic nervous system development, neuroblasts express a programmed cascade of five temporal transcription factors that govern the identity of cells generated at different time-points. However, these five temporal genes fall short of accounting for the many distinct cell types generated in large lineages. Here, we find that the late temporal gene castor sub-divides its large window in neuroblast 5-6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulatory program. The sub-temporal program acts both upon itself and upon the determination cascades to diversify the castor window. Surprisingly, the early temporal gene Kruppel acts as one of the sub-temporal genes within the late castor window. Intriguingly, while the temporal gene castor activates the two determination cascades and the sub-temporal program, spatial cues controlling cell fate in the latter part of the 5-6 lineage exclusively act upon the determination cascades.

PubMed ID
PubMed Central ID
PMC5065313 (PMC) (EuropePMC)
Related Publication(s)
Note

Re-utilization of a transcription factor.
Pinto-Teixeira and Desplan, 2016, eLife 5: e21522 [FBrf0239619]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference