FB2026_02 , released June 18, 2026
Allele: Dmel\cexKS181
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General Information
Symbol
Dmel\cexKS181
Species
D. melanogaster
Name
FlyBase ID
FBal0030740
Feature type
allele
Associated gene
cex
Associated Insertion(s)
Carried in Construct
Also Known As
cex1
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  alcohol use disorder
        CEA
        (Scholz et al., 2000)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Show significantly reduced ability to develop ethanol tolerance.

        (Scholz et al., 2000)

        The architecture of the protocerebral bridge is disturbed in cexKS181 adult brains; it looks more 'glomerular' than wild type. Total walking activity is significantly decreased in comparison to wild-type flies. Episodes of high walking probability occur as frequently as in wild-type flies, but these episodes are of much shorter duration than in wild type.

        (Martin et al., 1999)

        Homozygous larvae show reduced locomotor behaviour (shorter path lengths) on agar (non-foraging surface) and yeast (foraging surface) compared to controls. Larvae are slower than controls in a roll over test.

        (Varnam et al., 1996)

        Protocerebral bridge of central body segmented showing its 16 glomeruli. Fan shaped body and ellipsoid body affected along the midline, often with a cleft in the fan body and a ventral opening in the ellipsoid body. Noduli occasionally fragmented or fused.

        (Strauss and Heisenberg, 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Strains differ from wild type in one or more larval behavioural assays.

        (Varnam and Sokolowski, 1995)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        cex1
        (Hitier et al., 2000, Scholz et al., 2000, Martin et al., 1999, Varnam et al., 1996)
        cexKS181
        Name Synonyms
        Secondary FlyBase IDs
        • FBal0001593
        References (10)