FlyBase Allele Report: Dmel\eya[3]

General Information

Symbol

Dmel\eya³

Species

D. melanogaster

Name

FlyBase ID

FBal0030760

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

roo{}eya³

Carried in Construct

Also Known As

eya^3cs

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Bonini et al., 1998)

Progenitor genotype

Associated Insertion(s)

roo{}eya³

Cytology

Description

roo insertion into the 5' untranslated region of the type I eya transcript. The insertion duplicates 5bp of genomic sequence.

(Zimmerman et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with eya¹)

(Tian et al., 2019)

abnormal size | adult stage (with eya²)

(Tian et al., 2019)

abnormal size | adult stage (with eya^cs)

(Tian et al., 2019)

abnormal size | adult stage (with In(2LR)ETD2.2)

(Tian et al., 2019)

female sterile

(Fabrizio et al., 2003, Zimmerman et al., 2000)

female sterile | recessive

(Bonini et al., 1998)

male sterile

(Fabrizio et al., 2003)

male sterile (with Df(2L)eya¹⁰)

(Fabrizio et al., 2003)

partially lethal - majority die

(Fabrizio et al., 2003)

viable

(Tian et al., 2019, Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998)

visible | adult stage (with eya¹)

(Tian et al., 2019)

visible | adult stage (with eya²)

(Tian et al., 2019)

visible | adult stage (with eya⁴)

(Tian et al., 2019)

visible | adult stage (with eya^cs)

(Tian et al., 2019)

visible | adult stage (with In(2LR)ETD2.2)

(Tian et al., 2019)

visible | recessive

(Bonini et al., 1998, Leiserson et al., 1998, Bonini et al., 1993)

visible | recessive | cold sensitive

(Zimmerman et al., 2000)

Phenotype Manifest In

eye

(Fabrizio et al., 2003, Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998, Sheng et al., 1997)

eye (with eya¹)

(Tian et al., 2019)

eye (with eya²)

(Tian et al., 2019)

eye (with eya⁴)

(Tian et al., 2019)

eye (with eya^cs)

(Tian et al., 2019)

eye (with In(2LR)ETD2.2)

(Tian et al., 2019)

germarium (with eya^E(P)10)

(Bai and Montell, 2002)

germline cell (with eya^E(P)10)

(Bai and Montell, 2002)

ocellus

(Zimmerman et al., 2000, Bonini et al., 1998)

ommatidium

(Sheng et al., 1997)

primary spermatocyte cyst (with Df(2L)eya¹⁰)

(Fabrizio et al., 2003)

spermatid (with Df(2L)eya¹⁰)

(Fabrizio et al., 2003)

spermatocyte (with Df(2L)eya¹⁰)

(Fabrizio et al., 2003)

Detailed Description

Statement

Reference

eya³/eya⁴ adults are eyeless.

eya¹/eya³ and eya¹/eya⁴ adults do not exhibit any differences in the number of ommatidia in the eye while adults containing either genotype exhibit significantly higher number of ommatidia in the eye than eya¹/eya^E1 eya¹/eya^E4 and eya¹/eya^cli-IID adults.

eya²/eya³ adults exhibit significantly higher number of ommatidia in the eye than eya²/eya^E1, eya²/eya^E4, eya²/eya^54C2 and eya²/eya^D3 but not eya²/eya^cli-IID adults.

eya^cs/eya³ adults exhibit greater number of ommatidia than eya^cs/eya^cs, eya^cs/eya^cli-IID, eya^cs/eya^E4 and eya^cs/T(2;3;4)ETD4.3 adults.

(Tian et al., 2019)

Less eya³ homozygotes eclose than wild-type, and those that do have severely reduced eyes, and are both male and female sterile. The testes of eya³/Df(2L)eya¹⁰ flies are shorter and thinner than wild-type, and are generally devoid of cells in the postmeiotic stages of spermatogenesis. Instead, the lumen's of these testes accumulate rounded up spermatocyte cysts with varying degrees of expressivity. Large clusters of these spermatocytes are apoptotic (assessed by acridine orange staining). Degenerating spermatocytes do not lose their encapsulation by somatic cells.

(Fabrizio et al., 2003)

eya³/eya^E(P)10 have egg chambers which contain abnormal germline cells. In extreme cases, ovarian development ceases in the germarium and the germarium appears swollen compared to wild type.

(Bai and Montell, 2002)

Homozygotes have reduced eyes and ocelli. Cold-sensitive allele.

(Zimmerman et al., 2000)

Homozygotes may be eyeless, or may have eyes that are up to less than 3/4 normal size. Ocelli are also lost. eya³/eya¹ flies have eyes that are between 3/4 and less than normal size.

Female fertile in combination with eya¹, eya², eya⁴ or eya^cli-IID. Female sterile in combination with eya^D1.

Produces eyeless flies in combination with eya^E1, eya^E2, eya^E5, eya^E8, eya^E10 or eya^cli-IID. Produces flies which are either eyeless or have reduced eyes in combination with eya⁴, eya^E4, eya^Z283, eya^D1, eya^D2, eya^D3, eya^D4, eya^D5, eya^D6 or eya^D7. Produces flies with reduced eyes in combination with eya^E6, eya^E9 or eya^E11.

(Bonini et al., 1998)

eya³/eya^E3 flies are viable, and have eyes which range from 1/2 to less than normal size. eya³/eya⁴ flies have eyes which are less than 1/2 normal size.

(Leiserson et al., 1998)

Compound eyes are reduced in size, having approximately 25% of the wild-type number of ommatidia.

(Sheng et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya¹

(Tian et al., 2019)

eya²

(Tian et al., 2019)

Fails to complement

eya⁴

(Tian et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

D. Mohler.

(Bonini et al., 1993)

Comments

eya³ and eya⁴ form an intragenic complementation group that interacts with eya¹ and eya².

(Leiserson et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cli^eya-3

eya³

(Tian et al., 2019)

eya^3cs

(Fabrizio et al., 2003, Bai and Montell, 2002, Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close