arm⁴; crb^D88-3 double mutants exhibit a severe crb-like cuticle phenotype.

First defects in zonula adherens formation are seen at the onset of germband extension on the dorsal side of the embryo in the developing amnioserosa. The distribution of adherens junction material at the apicolateral boundary is more irregular.

Strong crb phenotype. Embryos almost completely lack cuticle: due to cell death in epidermal primordium. P{lacZ}6-81 enhancer detection line specifically expresses Ecol\lacZ in the tracheal system, and reveals that morphogenetic abnormalities in the developing tracheal system result in a few aggregates of tracheal cells only. Morphogenetic abnormalities and cell death were detected in the presumptive foregut and hindgut by fkh protein staining. Salivary glands also undergo cell death.