FB2026_02 , released June 18, 2026
Allele: Dmel\crbS87-2
Open Close
General Information
Symbol
Dmel\crbS87-2
Species
D. melanogaster
Name
FlyBase ID
FBal0030958
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pellikka et al., 2002, Tepass and Knust, 1990)
Mutagen
X ray
(Tepass and Knust, 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Tepass and Knust, 1990)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In mutant clones in the eye the ommatidia appear superficially normal. Rhabdomeres show similar defects to those of crb2, though with lower expressivity - rhabdomeres extend only 70% of their normal length and are confined to the distal part of the retina. Secondary and tertiary pigment cells die, though not until well after eclosion. Rhabdomeres are larger than normal and may touch each other. Photoreceptor cell stalk membrane is 25% shorter than wild type.

      (Pellikka et al., 2002)

      Variable phenotype. Some continuous patches of epidermal cuticle.

      (Tepass and Knust, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      crbS87-2 has embryonic/first instar larval cuticle phenotype, suppressible by yrt75

      (Laprise et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      yrt75 suppresses the zygotic cuticle phenotype of crb2 or crbS87-2 mutant embryos. Defects in junctional integrity and cellular organization of the epidermis are strongly rescued in double mutants compared to crb2 or crbS87-2 mutant embryos.

      (Laprise et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      crbS87-2
      (Laprise et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)