FlyBase Allele Report: Dmel\da[IIP106]

General Information

Symbol

Dmel\da^IIP106

Species

D. melanogaster

Name

FlyBase ID

FBal0031011

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Wulbeck et al., 1994, Bate et al., 1991)

loss of function allele

(Giebel et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Point mutation.

(Wulbeck et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Brand and Campos-Ortega, 1990)

lethal - all die during embryonic stage | recessive

(Wulbeck et al., 1994)

some die during embryonic stage

(Brand and Campos-Ortega, 1990)

some die during embryonic stage | recessive

(Wulbeck et al., 1994)

Phenotype Manifest In

embryonic/larval midgut | embryonic stage

(Wulbeck et al., 1994)

larval somatic muscle cell

(Wulbeck et al., 1994)

presumptive embryonic/larval nervous system

(Giebel et al., 1997)

sense organ | embryonic stage

(Wulbeck et al., 1994)

Detailed Description

Statement

Reference

Homozygous embryos lack all sensory organs, have hypoplasic defects and various defects in the somatic musculature and midgut.

(Wulbeck et al., 1994)

Enhance the spl alleles of N phenotype. Dominant effects of da mutations on spl alleles of N are due to haploinsufficiency.

(Brand and Campos-Ortega, 1990)

In double mutant embryos, in combination with amorphic neurogenic mutations, only neural cells that do not require a particular gene of the ASC develop to a neural fate.

(Brand and Campos-Ortega, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

da^IIP106/da^KE383 has lethal | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106/da^KE383 has lethal | embryonic stage phenotype, suppressible | partially by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^IIP106 has lethal | recessive | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106 has lethal | recessive | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

Suppressor of

Statement

Reference

da^IIP106 is a suppressor of visible phenotype of Scer\GAL4^455.2, l(1)sc^UAS.cHa

(Rottgen et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

da^IIP106 has sense organ | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^IIP106 has embryonic/larval midgut | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^IIP106/da^KE383 has phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106/da^KE383 has phenotype, suppressible | partially by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^IIP106 has larval somatic muscle cell phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106 has sense organ | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106 has embryonic/larval midgut | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106 has larval somatic muscle cell phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

Suppressor of

Statement

Reference

da^IIP106 is a suppressor of scutellar bristle phenotype of Scer\GAL4^455.2, l(1)sc^UAS.cHa

(Rottgen et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Mutation suppresses the ectopic scutellar bristle phenotype seen from Scer\GAL4^455.2-mediated expression of l(1)sc^Scer\UAS.cHa.

(Rottgen et al., 1998)

Xenogenetic Interactions

Statement

Reference

Embryonic phenotype can be rescued by constructs carrying da::Brer\E12^HLH or da::Brer\E12^bHLH but no flies emerge. Embryonic lethality is rescued but flies die as larvae. da^IIP106/da^KE383 transheterozygotes carrying da::Brer\E12^HLH survive to adulthood. Flies exhibit defects in wings and sensory organs. da::Brer\E12^bHLH does not allow rescue to adulthood.

(Wulbeck et al., 1994)

Complementation and Rescue Data

Rescued by

da^IIP106 is rescued by Scer\GAL4^da.G32/da^UAS.cGa

(Giebel et al., 1997)

Comments

PNS and CNS defects are completely rescued by Scer\GAL4^da.G32-mediated expression of da^Scer\UAS.cGa.

(Giebel et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

da^IIP106

l(2)IIP106

(Bate et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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