FlyBase Allele Report: Dmel\dpp[hr93]

General Information

Symbol

Dmel\dpp^hr93

Species

D. melanogaster

Name

FlyBase ID

FBal0031072

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wharton et al., 1996, Wharton et al., 1993)

Progenitor genotype

Cytology

Description

No unique changes were found on sequencing the dpp coding region or 5' and 3' untranslated regions.

(Wharton et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Wharton et al., 1993)

lethal - all die during embryonic stage

(Wharton et al., 1996)

some die during embryonic stage

(Wharton et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

(Wharton et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dpp^hr93, sax[+]/sax¹ has lethal | dominant phenotype

(Xie et al., 1994)

dpp^hr93, sax[+]/sax² has lethal | dominant phenotype

(Xie et al., 1994)

dpp^hr93/dpp[+], sax¹ has lethal | dominant phenotype

(Xie et al., 1994)

dpp^hr93/dpp[+], sax² has lethal | dominant phenotype

(Xie et al., 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^hr93 has phenotype, enhanceable by tld¹⁴

(Raftery et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Shows a dominant lethal interaction with sax¹ and sax² : flies transheterozygous for dpp^hr27 or dpp^hr93 and sax¹ or sax² fail to eclose.

(Xie et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Blackman.

(Wharton et al., 1993)

Comments

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93 < dpp^H94 < dpp^H95 < dpp^H96 = dpp^H91 = dpp^H46.

(Wharton et al., 1993)

Phenotypic series: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93.

(Childs and O'Connor, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp⁹³

(Iwaki and Lengyel, 2002)

dpp^hinr93

(Mellerick and Nirenberg, 1995)

dpp^hr93

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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