FB2026_02 , released June 18, 2026
Allele: Dmel\tld14
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General Information
Symbol
Dmel\tld14
Species
D. melanogaster
Name
FlyBase ID
FBal0016885
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Also Known As
tld10E, tld10E95
Key Links
Genomic Maps

Allele class

loss of function allele

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Marques et al., 1997, Raftery et al., 1995, Childs and O'Connor, 1994, Finelli et al., 1994, Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992)

loss of function allele

(Ray et al., 1991)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: S276F. Nucleotide substitution: C827T. Mutation within the protease domain.

(Childs and O'Connor, 1994)

The mutation falls in the protease domain of the tld protein.

(Finelli et al., 1994)

Amino acid replacement: S276F.

(Finelli et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,750,913..24,750,913 [+]
Nucleotide change:

C24750913T

Reported nucleotide change:

C827T

Amino acid change:

S286F | tld-PA

Reported amino acid change:

S276F

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Childs and O'Connor, 1994)
point_mutation
3R:24,750,913..24,750,913 [+]
Nucleotide change:

C24750913T

Reported nucleotide change:

C?T

Amino acid change:

S286F | tld-PA

Reported amino acid change:

S276F

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Finelli et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junctions appear normal in structure and localisation in tld9/tld14 third instar larvae.

      (Meyer and Aberle, 2006)

      Homozygous embryos form some residual visceral mesoderm. The dorsal vessel is missing, except for a few residual cells.

      (Yin and Frasch, 1998)

      Antagonistic activity towards dpp.

      (Childs and O'Connor, 1994)

      Strong ventralization. Dominantly enhances dpp phenotype.

      (Finelli et al., 1994)

      Moderate ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

      (Arora and Nusslein-Volhard, 1992)

      Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

      (Ray et al., 1991)

      strong

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      tld1/tld14 has lethal phenotype, suppressible by sogY506

      (Ferguson and Anderson, 1992)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      tld14 is an enhancer of phenotype of dpp98

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp97

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp99

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dppe90

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp100

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp101

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpphr92

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpphr27

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dppd-ho

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpphr89

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp102

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpphr4

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpphr93

      (Raftery et al., 1995)

      tld14 is an enhancer of phenotype of dpp103

      (Raftery et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Strong enhancer of all dpp alleles, except dppe87 and dpphr56.

      (Raftery et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tldMBT

      (Riede, 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong tld allele. Allelic series for tld antagonistic effect on dpp : tldB3 > tld14 = tld6 > tld1 > tld6P41 > tld9Q19.

      (Childs and O'Connor, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (12)