FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fzy3
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General Information
Symbol
Dmel\fzy3
Species
D. melanogaster
Name
FlyBase ID
FBal0031372
Feature type
allele
Associated gene
Dmel\fzy
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Philp and Glover, 1997, Sigrist et al., 1995, Dawson et al., 1993)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roote, 1995.5.4)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show metaphase arrest with compact condensed chromosomes.

      (Donaldson et al., 2001)

      thr1 fzy3 double mutants block temporarily in cycle 15, but then enter mitosis 16 on schedule. Ventral epidermal cells become permanently blocked in metaphase in mitosis 16, similar to fzyunspecified single mutants. thr1 fzy3 pimIL triple mutants have a similar phenotype to fzyunspecified single mutants.

      (Philp and Glover, 1997)

      Cells in the ventral epidermis frequently become arrested in metaphase in homozygous embryos. This phenotype is not altered in Df(1)bi-D3/Y ; fzy3/fzy3 embryos. Cells in the dorsal epidermis of these double mutants enter an extra division cycle after mitosis 16 (as is seen for Df(1)bi-D3/Y single mutant embryos), and these cells become arrested during metaphase of this extra division.

      (Sigrist and Lehner, 1997)

      The maternal fzy contribution is stable enough to allow completion of mitotic proliferation in the dorsal epidermis, but not in the ventral epidermis. fzy3 embryos carrying P{Dmcdc2A171T} at 18oC exhibit mitotic arrest at stage 11 in the ventral region, as expected. Temperature shift to the restrictive temperature causes a drastic reduction in the number of metaphase arrested cells.

      (Sigrist et al., 1995)

      Ventral epidermis absent, CNS degenerate, PNS absent.

      (Dawson et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      fzy3 has phenotype, suppressible by Scer\GAL4prd.RG1/fzr2UAS.cJa

      (Jacobs et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)H60-3/fzy3 is rescued by fzytDa

      (Dawson et al., 1995)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      S. Roth.

      (Roote, 1995.5.4)
      Comments
      Comments

      Phenotypic data included in FBrf0051973.

      (Roote, 1995.5.4)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      X4
      (Roote, 1995.5.4)
      fizzyx4
      (Donaldson et al., 2001)
      fzy3
      (Sarov et al., 2016, Derive et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)