Open Close
General Information
Symbol
Dmel\fzy3
Species
D. melanogaster
Name
FlyBase ID
FBal0031372
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants show metaphase arrest with compact condensed chromosomes.

thr1 fzy3 double mutants block temporarily in cycle 15, but then enter mitosis 16 on schedule. Ventral epidermal cells become permanently blocked in metaphase in mitosis 16, similar to fzyunspecified single mutants. thr1 fzy3 pimIL triple mutants have a similar phenotype to fzyunspecified single mutants.

Cells in the ventral epidermis frequently become arrested in metaphase in homozygous embryos. This phenotype is not altered in Df(1)bi-D3/Y ; fzy3/fzy3 embryos. Cells in the dorsal epidermis of these double mutants enter an extra division cycle after mitosis 16 (as is seen for Df(1)bi-D3/Y single mutant embryos), and these cells become arrested during metaphase of this extra division.

The maternal fzy contribution is stable enough to allow completion of mitotic proliferation in the dorsal epidermis, but not in the ventral epidermis. fzy3 embryos carrying P{Dmcdc2A171T} at 18oC exhibit mitotic arrest at stage 11 in the ventral region, as expected. Temperature shift to the restrictive temperature causes a drastic reduction in the number of metaphase arrested cells.

Ventral epidermis absent, CNS degenerate, PNS absent.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

fzy3 has phenotype, suppressible by Scer\GAL4prd.RG1/fzr2UAS.cJa

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

S. Roth.

Comments
Comments

Phenotypic data included in FBrf0051973.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (11)