FB2026_02 , released June 18, 2026
Allele: Dmel\hrycosh
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General Information
Symbol
Dmel\hrycosh
Species
D. melanogaster
Name
FlyBase ID
FBal0031446
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
P{cosh}
Also Known As
cosh
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rushlow et al., 1989)
Progenitor genotype
Carried in construct
P{cosh}
Cytology
Description

28kb XhoI fragment that includes about 14kb of DNA upstream of the α1 promoter.

(Rushlow et al., 1989)
Allele components
Component
Use(s)
Regulatory region(s)
hry
Encoded product / tool
hry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The adult flies display the h bristle phenotype that is not rescued by h transgenes.

      (Lardelli and Ish-Horowicz, 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      hrycosh partially rescues hryunspecified

      (Orenic et al., 1993)

      hrycosh partially rescues hry41/hry25

      (Rushlow et al., 1989)

      hrycosh partially rescues hry1

      (Rushlow et al., 1989)

      hrycosh partially rescues hry2

      (Rushlow et al., 1989)
      Comments

      Rescues the embryonic segmentation defect but not the adult wing defect of h mutations. Legs from hcosh; h-/h- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

      (Orenic et al., 1993)

      hcosh includes all sequences necessary for embryonic function of h by rescuing the segmentation defects. Individuals eclose and adults show normal segmentation pattern. The severe h bristle phenotype cannot be rescued.

      (Rushlow et al., 1989)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Expression demonstrates that cis-regulatory elements that regulate h expression in imaginal discs, except for those that drive the transverse stripes in the leg, lie outside the h region that is included in hcosh.

      (Orenic et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hcosh
      hrycosh
      Name Synonyms
      Secondary FlyBase IDs
        References (4)