FlyBase Allele Report: Dmel\peb[EH704a]

General Information

Symbol

Dmel\peb^EH704a

Species

D. melanogaster

Name

FlyBase ID

FBal0031499

Feature type

allele

Associated gene

Dmel\peb

Associated Insertion(s)

Carried in Construct

Also Known As

hnt^EH704a

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Yip et al., 1997, Eberl and Hilliker, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Yip et al., 1997, Eberl and Hilliker, 1988)

some die during embryonic stage | recessive

(Yip et al., 1997, Eberl and Hilliker, 1988)

visible | somatic clone

(Pickup et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

peb¹/peb^EH704a transheterozygous egg chambers show a significant decrease in follicle rupture (ex vivo, octopamine-treated egg chambers), as compared to peb¹ heterozygous controls.

(Deady et al., 2017)

Homozygous clones in the eye result in a scar. Mutant cells in larval eye discs show depletion or more diffuse localisation of F-actin, especially in the more posterior part of the mutant clone.

(Pickup et al., 2002)

65.8% of embryos exhibit a germband retraction phenotype, 20.5% a dorsal closure phenotype. 60% of embryos that complete germ band retraction exhibit an anterior-open or dorsal-hole phenotype characteristic of the failure of dorsal closure.

(Reed et al., 2001)

Genetic mosaic embryos show phenotypes that reveal a correlation between the genotype of the amnioserosa and the success or failure of germ band retraction.

(Lamka and Lipshitz, 1999)

Embryos show intermediate failure of germband retraction. 36% have abdominal segment 6.5 or greater at the posterior tip.

(Yip et al., 1997)

Variably incomplete germ band retraction.

(Eberl and Hilliker, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

peb^EH704a has mitotic domain 1 | extended germ band stage phenotype, suppressible by InR^hs.PF

(Lamka and Lipshitz, 1999)

peb^EH704a has embryo | dorsal closure stage phenotype, suppressible by InR^hs.PF

(Lamka and Lipshitz, 1999)

NOT suppressed by

Statement

Reference

peb^EH704a has amnioserosa phenotype, non-suppressible by InR^hs.PF

(Lamka and Lipshitz, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

InR^hs.PF partially suppresses the germ band retraction defect of peb^EH704a embryos. The amnioserosa apoptosis defect is not suppressed.

(Lamka and Lipshitz, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

peb¹

(Pickup et al., 2002)

peb¹

(Yip et al., 1997)

Rescued by

peb^EH704a is rescued by peb^hs.PY

(Yip et al., 1997)

Comments

The failure of germband retraction can be rescued by peb^hs.PY.

(Yip et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

l(1)EH275a is not allelic to peb; l(1)EH275a¹ complements peb^hnt-1, peb^X001, peb^EH704a and peb¹.

(Yip et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

hnt^704a

(Reed et al., 2001)

hnt^EH704a

(Deady et al., 2017, Jia et al., 2014, Wilk et al., 2004, Pickup et al., 2002, Lamka and Lipshitz, 1999)

l(1)EH704a

(Eberl and Hilliker, 1988)

peb^EH704a

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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