FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hydhs1
Open Close
General Information
Symbol
Dmel\hydhs1
Species
D. melanogaster
Name
FlyBase ID
FBal0031510
Feature type
allele
Associated gene
Dmel\hyd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        hydhs1/hydC017 mutants exhibit abnormalities in spermatogenesis. One such abnormality is for nuclei scattered through the elongated cysts to exhibit a round shape instead of a 'needle' shape. In rare cases, the group of needle-shaped nuclei can be found in the correct place in the cyst; however, some of the nuclei are evidently incorrectly condensed. Approximately 90% of nuclei and micronuclei do not reach the correct cyst pole.

        (Pertceva et al., 2010)

        At 25oC homozygotes show hyperplastic imaginal disc overgrowth, affecting wing, haltere and eye-antennal discs, whereas at 18oC development proceeds normally. Mutant discs implanted into wild type hosts for metamorphosis overgrow and differentiate normal imaginal structures. Mutant larvae do not grow beyond the maximum size seen for wild type. A few escapers eclose as adults.

        (Sehnal and Bryant, 1993)

        Imaginal discs show gap-junctional communication defects: coupling is severely diminished.

        (Jursnich et al., 1990)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        hydhs1 has abnormal cytokinesis phenotype, enhanceable by pAbp[+]/pAbpk10109

        (Pertceva et al., 2010)
        Enhancer of
        Statement
        Reference

        hyd[+]/hydhs1 is an enhancer of abnormal cytokinesis phenotype of pAbpk10109

        (Pertceva et al., 2010)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        pAbpk10109/hydhs1 trans-heterozygous double mutants exhibit spermatogenesis defects. Approximately 30% of head bundles in the sperm contain both round- and needle-shaped nuclei. Abnormal nuclei scattering occurs at low frequency. Cytokinetic abnormalities are also increased in these double mutants.

        (Pertceva et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        hydhs1
        (Pertceva et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)