FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wekRAR14
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General Information
Symbol
Dmel\wekRAR14
Species
D. melanogaster
Name
FlyBase ID
FBal0031715
Feature type
allele
Associated gene
Dmel\wek
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Chen et al., 2006)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Ashburner et al., 1990)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q88term.

(Chen, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,767,910..15,767,910 [-]
Nucleotide change:

C15767910T

Amino acid change:

Q88term | wek-PA; Q88term | wek-PB

Reported amino acid change:

Q88term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chen, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos

      derived from mothers homozygous mutant for wekRAR14 in the germline develop dorsalized cuticular structures with a range of phenotypes. 12% of these embryos show an extreme dorsalized phenotype as they secrete a hollow tube of dorsal epidermis. 81% lack ventral and lateral structures but retain the dorsolaterally derived filzkorper and 7% show cuticles which contain both filzkorper and a few ventral denticle belts.

      (Chen et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      weklor

      (Chen et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on the extent of the dorsalized phenotype in embryos from germ-line clones, the following wek alleles can be ranked from strongest to weakest as follows: wekEX14 > wekRAR14 > weklor.

      (Chen et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)35EaRAR14
      (Ashburner et al., 1999.10.12, Ashburner et al., 1990)
      wekRAR14
      (Kahsai and Cook, 2018, Chen, 2006, Chen et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)