FB2026_02 , released June 18, 2026
Allele: Dmel\weklor
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General Information
Symbol
Dmel\weklor
Species
D. melanogaster
Name
lotus root
FlyBase ID
FBal0194092
Feature type
allele
Associated gene
Dmel\wek
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chen et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: I115M.

(Chen, 2006)

Amino acid replacement: T323S.

(Chen, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,767,205..15,767,205 [-]
Nucleotide change:

A15767205T

Amino acid change:

T323S | wek-PA; T323S | wek-PB

Reported amino acid change:

T323S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chen, 2006)
point_mutation
2L:15,767,827..15,767,827 [-]
Nucleotide change:

A15767827G

Amino acid change:

I115M | wek-PA; I115M | wek-PB

Reported amino acid change:

I115M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chen, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos

      derived from mothers homozygous mutant for weklor in the germline develop dorsalized cuticular structures with a range of phenotypes. 33% of these embryos show a moderately dorsalized phenotype; they have the dorsolaterally derived filzkorper but lack the eight ventrally derived denticle belts. 59% show weak dorsalized phenotypes as they still contain both filzkorper and a few denticle belts. 8% of embryos have a wild-type appearance and hatch.

      Although weklor/wekEX14 transheterozygotes are pupal lethal, some survive to adulthood but have crooked legs.

      Embryos derived from weklor/wekEX14 mothers exhibit a dorsalized phenotype that is weaker than embryos derived from wekEX14 mothers, but stronger than embryos derived from weklor mothers.

      (Chen et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      weklor, cact7 embryos show a lateralized phenotype, as revealed by the presence of rings of laterally derived ventral denticle belts.

      Embryos produced by weklor/wekEX14; Tl3/+ mothers show a biphasic phenotype distribution. 76% show a moderately dorsalized phenotype; these embryos lack ventral and lateral structures but retain the dorsolaterally-derived filzkorper. 24% show a lateralized phenotype; these embryos are elongated and thin in appearance and contain fine rings of laterally-derived ventral denticle belts.

      (Chen et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a zygotic lethal mutation with maternal effect from a large genetic screen.

      (Chen et al., 2006)
      Comments
      Comments

      Based on the extent of the dorsalized phenotype in embryos from germ-line clones, the following wek alleles can be ranked from strongest to weakest as follows: wekEX14 > wekRAR14 > weklor.

      (Chen et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      weklor
      (Chen, 2006, Chen et al., 2006)
      Name Synonyms
      lotus root
      Secondary FlyBase IDs
        References (2)