FlyBase Allele Report: Dmel\wek[05271a]

General Information

Symbol

Dmel\wek^05271a

Species

D. melanogaster

Name

FlyBase ID

FBal0101331

Feature type

allele

Associated gene

Dmel\wek

Associated Insertion(s)

P{PZ}wek^05271a

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gates and Thummel, 2000, Roote, 2000.6.13, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}wek^05271a

Cytology

Description

A P{PZ} insertion at nucleotide 6 of wek.

(Chen et al., 2006)

P{PZ} insertion in the first exon.

(Ashburner et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:15,768,312..15,768,312

(Chen et al., 2006, Gates and Thummel, 2000, Roote, 2000.6.13, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Gates and Thummel, 2000, Ashburner et al., 1999)

viable

(Gates and Thummel, 2000, Ashburner et al., 1999)

visible | recessive

(Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Phenotype Manifest In

leg

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

wing

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Detailed Description

Statement

Reference

Hemizygotes are viable and fertile and have no obvious defects.

(Gates and Thummel, 2000)

Hemizygotes have crippled legs and small wings.

(Ashburner et al., 1999)

Hemizygotes have a weak crippled leg and reduced wing phenotype.

(Ashburner et al., 1999.10.12)

No obvious phenotype.

(Spradling et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

wek^lor

(Chen et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a separable lethal. The P{PZ}wek^05271a insertion is viable and fertile over deletions of the 34-36 region, including 35D, indicating that the P{PZ} insertion is not associated with the lethality of the "l(2)05271" strain.

(Ashburner et al., 1999.10.12)

Separable from: l(2)05271b^05271b. The P{PZ}wek^05271a insertion is viable and fertile with no obvious defects in combination with deficiences covering the site of the P{PZ} insertion, indicating that the phenotype of the "l(2)05271" line (caused by l(2)05271b^05271b) is separable from the P{PZ}wek^05271a insertion.

(Gates and Thummel, 2000)

Comments

1 excision out of 14, Df(2L)PZ05271-rv54, is lethal.

(Roote, 2000.6.13)

No P-element excision events that result in the reversion of the malformed leg and lethal phenotypes of the "l(2)05271" line have been recovered (out of nearly 100 events).

(Gates and Thummel, 2000)

Complements: crp⁰⁰²³². Complements: CycE⁰⁵²⁰⁶. Complements: CycE⁰⁵²⁷⁷. Complements: CG15269⁰⁵⁴⁴¹. Complements: esg⁰⁵⁷²⁹. Complements: esg⁰⁵⁷³⁰. Complements: gft⁰⁶⁴³⁰. Complements: esg⁰⁷⁰⁸². Complements: CycE¹⁰⁴²⁷.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

PZ05271

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

l(2)05271

(Chen, 2006, Gates and Thummel, 2000)

l(2)35Ea^05271a

(Roote, 2000.6.13, Ashburner et al., 1999, BDGP Project Members, 1994-1999)

n(2)05271

(Spradling et al., 1999)

wek⁰⁵²⁷¹

wek^05271a

wek^l(2)05271

(Chen et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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