FlyBase Allele Report: Dmel\heix[1]

General Information

Symbol

Dmel\heix¹

Species

D. melanogaster

Name

FlyBase ID

FBal0031718

Feature type

allele

Associated gene

Dmel\heix

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Roote, 1995.5.4)

Progenitor genotype

Cytology

Description

Amino acid replacement: A144R.

(Xia et al., 2015)

An AR144 mutation resulting from a G to A base change in the last residue of the only intron, and is expected to result in an aberrant splicing event.

(Xia et al., 2015)

Nucleotide substitution: G?A.

(Xia et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,298,194..16,298,194 [-]

Nucleotide change:

G16298194A

Comment:

G to A mutation in the splice acceptor of the only heix intron.

(Xia et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of lymphoma

CEA with heix^k11403

(Dragh et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Pink1^B9

(Vos et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage (with Df(2L)RA5)

(Xia et al., 2015)

decreased body size | pupal stage (with Df(2L)RA5)

(Xia et al., 2015)

lethal (with Df(2L)RA5)

(Xia et al., 2015)

lethal (with heix^k11403)

(Xia et al., 2015)

melanotic mass phenotype (with heix^k11403)

(Xia et al., 2015)

Phenotype Manifest In

embryonic/larval hemocyte | increased number (with heix^k11403)

(Xia et al., 2015)

lamellocyte (with heix^k11403)

(Xia et al., 2015)

melanotic mass (with heix^k11403)

(Xia et al., 2015)

primary lobe of embryonic/larval lymph gland (with heix^k11403)

(Xia et al., 2015)

secondary lobe of embryonic/larval lymph gland (with heix^k11403)

(Xia et al., 2015)

Detailed Description

Statement

Reference

Most heix^k11403/heix¹ flies produce melanotic masses in larval or pupal stage. Mutant larvae present an enormous overgrowth of the lymph gland. This event is coupled with a dramatic increase of circulating hemocytes and an aberrant differentiation of lamellocytes. The size of primary lobes in heix^k11403/heix¹ mutant lymph glands is about two times and four times larger than that in the control, respectively; the size of secondary lobes in heix^k11403/heix¹ third instar larvae are approximately twenty times larger than that observed in controls.

A few heix¹/Df(2L)RA5 mutants survive to the larval and pupal stage and are smaller than their heterozygous siblings.

(Xia et al., 2015)

Feeding hemizygous animals with the MK-4 form of vitamin K[[2]], but not with menadione (a synthetic precursor that is prenylated to form vitamin K[[2]]) or with ubiquinone significantly improves their survival rate.

The mitochondrial membrane potential is less negative than wild type in hemizygous larvae.

(Vos et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

heix[+]/heix¹ is an enhancer of abnormal flight phenotype of Pink1^B9

(Vos et al., 2012)

Suppressor of

Statement

Reference

heix[+]/heix¹ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

heix[+]/heix¹ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

3600

Adc^b-1 heix¹ pr¹ cn¹ wx^wxt bw¹/CyO

Notes on Origin

Discoverer

S. Roth.

(Roote, 1995.5.4)

Comments

Phenotypic data included in FBrf0051973.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

AR144

(Roote, 1995.5.4)

heix¹

(Bellen, 2020.5.15, Dragh et al., 2017, Xia et al., 2015, Vos et al., 2012)

l(2)35Fc¹

(Ashburner et al., 1999.10.12, Roote, 1994.11.4)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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