FlyBase Allele Report: Dmel\mago[3]

General Information

Symbol

Dmel\mago³

Species

D. melanogaster

Name

FlyBase ID

FBal0032140

Feature type

allele

Associated gene

Dmel\mago

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Boswell et al., 1991)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Boswell et al., 1991)

Description

Amino acid replacement: Q87term.

(Newmark and Boswell, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:21,128,952..21,128,952 [+]

Nucleotide change:

C21128952T

Amino acid change:

Q87term | mago-PA

(Newmark and Boswell, 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)AA21)

(Kahsai and Cook, 2018)

lethal | recessive

(Micklem et al., 1997, Newmark et al., 1997, Newmark and Boswell, 1994)

lethal - all die during embryonic stage | maternal effect

(Boswell et al., 1991)

some die during embryonic stage | maternal effect

(Boswell et al., 1991)

Phenotype Manifest In

egg | germline clone

(Newmark et al., 1997)

oocyte nucleus

(Micklem et al., 1997)

oocyte nucleus | germline clone

(Newmark et al., 1997)

Detailed Description

Statement

Reference

Homozygous egg chambers show abnormal localisation of the oocyte nucleus.

(Micklem et al., 1997)

Homozygous female germline clones give rise to egg chambers containing mislocalised oocyte nuclei and ventralised eggs.

(Newmark et al., 1997)

Shows a grandchildless phenotype in trans to mago¹.

(Newmark and Boswell, 1994)

Grandchildless-like phenotype.

(Boswell et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mago³ has lethal phenotype, suppressible by Cele\mag-1^mago.PN

(Newmark et al., 1997)

Enhancer of

Statement

Reference

mago³/mago[+] is an enhancer of visible phenotype of rl¹

(Ashton-Beaucage et al., 2010)

Suppressor of

Statement

Reference

mago³/mago[+] is a suppressor of visible phenotype of Ras85D^V12.sev

(Ashton-Beaucage et al., 2010)

Other

Statement

Reference

Df(2R)BSC600/Pym^SH1616, mago³/mago[+] has lethal phenotype

(Ghosh et al., 2014)

Cele\mag-1^mago.PN, mago³ has viable phenotype

(Newmark et al., 1997)

Phenotype Manifest In

Enhancer of

Statement

Reference

mago³/mago[+] is an enhancer of eye phenotype of rl¹

(Ashton-Beaucage et al., 2010)

mago³/mago[+] is an enhancer of wing vein phenotype of rl¹

(Ashton-Beaucage et al., 2010)

Suppressor of

Statement

Reference

mago³/mago[+] is a suppressor of eye phenotype of Ras85D^V12.sev

(Ashton-Beaucage et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

mago³ dominantly suppresses the rough eye phenotype caused by Ras85D^V12.sev.

The loss of wing veins and rough eye phenotype seen in rl¹ homozygotes is dominantly enhanced by mago³.

(Ashton-Beaucage et al., 2010)

Xenogenetic Interactions

Statement

Reference

Two copies of Cele\mag-1^mago.PN are necessary to rescue the lethality of mago³.

(Newmark et al., 1997)

Complementation and Rescue Data

Rescued by

mago³ is rescued by mago^+t2.2

(Newmark and Boswell, 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

51289

w^*; P{neoFRT}42D mago³ shn³/CyO

51304

P{neoFRT}42D arr² mago³/T(2;3)TSTL14, SM5: TM6B, Tb¹

51303

P{neoFRT}42D mam¹⁰ mago³/T(2;3)TSTL14, SM5: TM6B, Tb¹

Notes on Origin

Discoverer

Comments

Germ line clonal analysis indicates that mago function is required in the germ line.

(Micklem et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mago³

(Toraason et al., 2024, Kahsai and Cook, 2018, Ghosh et al., 2014, Ashton-Beaucage et al., 2010, Roignant and Treisman, 2010, Baker et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close