FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\msl-2227
Open Close
General Information
Symbol
Dmel\msl-2227
Species
D. melanogaster
Name
FlyBase ID
FBal0032194
Feature type
allele
Associated gene
Dmel\msl-2
Associated Insertion(s)
Carried in Construct
Also Known As
msl2γ227
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: L?C. Frameshift induced mutations are adjacent and result in a truncated protein.

    (Zhou et al., 1995)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2L:3,464,988..3,464,988 [-]
    Comment:

    1bp deletion resulting in frame-shift and truncated polypeptide.

    (Zhou et al., 1995)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The reduced viability phenotype of Ime4Δ22-3;SxlfP7B0 double heterozygous daughters from Ime4Δ22-3 mutant females can be fully rescued by combination with msl-2227/Df(2L)Exel7016 although these females frequently show signs of sexual transformation and display male-specific features such as sex-combs, which are mosaic to various degrees.

        SxlfP7B0;msl-2227/Df(2L)Exel7016 females do not display any decrease in viability compared to controls.

        (Haussmann et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        msl-2kmA

        (Bevan et al., 1993)
        Comments

        msl-2kmA/msl-2227 males do not survive, dying as larvae.

        (Bevan et al., 1993)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (6)
        References (13)