FlyBase Allele Report: Dmel\pnr[VX4]

General Information

Symbol

Dmel\pnr^VX4

Species

D. melanogaster

Name

FlyBase ID

FBal0032466

Feature type

allele

Associated gene

Dmel\pnr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Heitzler et al., 1996, Ramain et al., 1993)

gain of function allele

(Heitzler et al., 1996)

Mutagen

X ray

(Heitzler et al., 1996, Ramain et al., 1993)

Progenitor genotype

Cytology

Description

17 nucleotide deletion, between nucleotides 1729 and 1745, causing a frameshift stop truncating the protein to 513 amino acids, and removing the putative α-helices.

(Ramain et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:16,039,924..16,039,940 [+]

Comment:

17 nucleotide deletion causing a frameshift stop truncating the protein to 513 amino acids

(Ramain et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Heitzler et al., 1996, Ramain et al., 1993)

visible | dominant

(Asmar et al., 2008, Heitzler et al., 1996, Ramain et al., 1993)

Phenotype Manifest In

anterior dorsocentral bristle

(Ramain et al., 1993)

dorsocentral bristle

(Asmar et al., 2008, Biryukova and Heitzler, 2008, Heitzler et al., 1996)

posterior dorsocentral bristle

(Ramain et al., 1993)

Detailed Description

Statement

Reference

Heterozygotes occasionally lack one dorsocentral bristle.

(Asmar et al., 2008)

pnr^VX4/+ flies occasionally lack one dorsocentral bristle.

(Biryukova and Heitzler, 2008)

Lethality occurs at larval or early pupal stages. Heterozygotes occasionally lack one dorsocentral bristle. Heterozygotes with pnr^V1 are viable.

(Heitzler et al., 1996)

Heterozygotes are missing one of the two dorsocentral bristles. Homozygous clones of cells are missing one or both bristles. Dominant phenotype enhanced in viable transallelic combinations with pnr^VX1. Homozygotes die as young larvae with no obvious mutant phenotype.

(Ramain et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

pnr^VX4 has visible | dominant phenotype, enhanceable by Bx^hdp-n60

(Asmar et al., 2008)

Other

Statement

Reference

pnr[+]/pnr^VX4, sens^E2 has visible | dominant phenotype

(Asmar et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

pnr^VX4 has dorsocentral bristle phenotype, enhanceable by Bx^hdp-n60

(Asmar et al., 2008)

Suppressed by

Statement

Reference

pnr^VX4 has dorsocentral bristle phenotype, suppressible by CtBP[+]/CtBP^rev19

(Biryukova and Heitzler, 2008)

Other

Statement

Reference

pnr[+]/pnr^VX4, sens^E2 has dorsocentral bristle phenotype

(Asmar et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Bx^hdp-n60/Y ; pnr^VX4/+ flies show a severe loss of dorsocentral bristles (significantly more loss is seen than in pnr^VX4/+ flies).

sens^E2/pnr^VX4 double heterozygotes show loss of dorsocentral bristles.

(Asmar et al., 2008)

pnr^VX4/CtBP^rev19 flies show an increase in the number of dorsocentral bristles.

(Biryukova and Heitzler, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36552

w¹¹¹⁸; st¹ pnr^VX4 e¹/TM3, P{ActGFP}JMR2, Ser¹

Notes on Origin

Discoverer

Comments

Class B allele.

(Ramain et al., 1993)

Class 3 pnr allele: dominant allele causing loss of bristles.

(Heitzler et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pnr^VX1/4

(Tomoyasu et al., 2000)

pnr^VX4

(Asmar et al., 2008, Biryukova and Heitzler, 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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