FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdgAKS60
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General Information
Symbol
Dmel\rdgAKS60
Species
D. melanogaster
Name
FlyBase ID
FBal0032561
Feature type
allele
Associated gene
Dmel\rdgA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Masai et al., 1993)
Mutagen
ethyl methanesulfonate
(Masai et al., 1997, Masai et al., 1993, Suzuki et al., 1990, Inoue et al., 1989)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rdgAKS60 mutants do not have the ability to discriminate between 18[o]C and temperatures between 20-24[o]C. The ability to choose 18[o]C over temperatures in the 14-16 and 26-32[o]C ranges is not impaired.

      (Kwon et al., 2008)

      Photoreceptor degeneration occurs during the first week of adult life. Diacylglycerol kinase activity is very low compared to wild-type.

      (Inoue et al., 1989)

      Rhabdomeres are small and irregular in shape one day after eclosion. Cisternae of the rough endoplasmic reticulum are more numerous than in normal retinular cells, submicrovillar cisternae are absent and fewer lysosomes than normal are seen. The degeneration of the mutant rhabdomeres proceeds more rapidly in regions remote from the nuclei.

      (Matsumoto et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      rdgAKS60 has phenotype, suppressible by su(rdgA)4040

      (Georgiev et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      rdgAKS60 flies lack diacylglycerol kinase activity in a gene dosage-dependent manner, suggesting that rdgA codes for diacylglycerol kinase.

      (Inoue et al., 1989)

      Incorporation of 3H-amino acids into the rhabdomeres is approximately half that of wild-type. Incorporation of 3H-sugar residues into the rhabdomeres is approximately 20% that of wild-type.

      (Suzuki et al., 1990)

      The level of ninaE protein in the rhabdomeric microvilli is reduced compared to wild-type.

      (Suzuki and Hirosawa, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rdgAKS60
      (Georgiev et al., 2012, Kwon et al., 2008, Kwon and Montell, 2006, Kwon and Montell, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)