FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\robo18
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General Information
Symbol
Dmel\robo18
Species
D. melanogaster
Name
FlyBase ID
FBal0032595
Feature type
allele
Associated gene
Dmel\robo1
Associated Insertion(s)
Carried in Construct
Also Known As
robo8
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kidd et al., 1998)
Mutagen
ethyl methanesulfonate
(Kidd et al., 1998, Seeger et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fas2-positive longitudinal axons show repeated crossing of the midline in robo1/robo8 stage 16 embryos.

      (Spitzweck et al., 2010)

      The pCC/MP2 pathway crosses back and forth across the midline in every segment in homozygous embryos.

      (Fritz and VanBerkum, 2000)

      "Fuzzy commisure" phenotype in embryonic central nervous system.

      (Seeger et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The number of embryos displaying abnormal midline crossing of axons increases from 5% in Khc::Ggal\MLCKKA.ftz heterozygotes to just over 60% if the embryos are also heterozygous for robo8.

      (Kim et al., 2001)

      In robo8 homozygous embryos that also carry Khc::Ggal\MLCKKA.ftz, small gaps in the longitudinal connectives start to appear in addition to the robo8 phenotype.

      (Fritz and VanBerkum, 2000)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: Fas3 null chromosome.

      (Kidd et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Z3127
      (Kidd et al., 1998)
      robo18
      (Huang et al., 2022, Spitzweck et al., 2010)
      robo8
      (Bahri et al., 2009, Kim et al., 2001)
      roboZ3127
      (Sekine et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)