FlyBase Allele Report: Dmel\sca[OB7]

General Information

Symbol

Dmel\sca^OB7

Species

D. melanogaster

Name

FlyBase ID

FBal0032662

Feature type

allele

Associated gene

Dmel\sca

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Hu et al., 1995)

loss of function allele

(Baker and Zitron, 1995)

Mutagen

ethyl methanesulfonate

(Hu et al., 1995, Baker et al., 1992, Baker et al., 1990, Mlodzik et al., 1990)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G517A.

(Hu et al., 1995)

Amino acid replacement: W173term.

(Hu et al., 1995, Baker et al., 1990)

Nucleotide substitution: G816A.

(Baker et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,784,411..12,784,411 [+]

Nucleotide change:

G12784411A

Reported nucleotide change:

G517A

Amino acid change:

W198term | sca-PA; W198term | sca-PB

Reported amino acid change:

W173term

Comment:

TGG to TAG

(Baker et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Lee et al., 1998, Baker et al., 1992)

Phenotype Manifest In

adult thorax & macrochaeta

(Lee et al., 1998)

eye

(Baker et al., 1992)

eye disc

(Baker et al., 1992)

eye photoreceptor cell

(Baker et al., 1992)

eye photoreceptor cell | increased number

(Baker et al., 1992)

ommatidium

(Baker et al., 1992)

photoreceptor cell R8 | somatic clone

(Li et al., 2003)

Detailed Description

Statement

Reference

In sca^OB7 somatic clones, the spacing of the R8 photoreceptors is irregular and extra R8 cells are seen. Possible cell non-autonomous defects are sometimes seen in these clones.

(Li et al., 2003)

sca^OB7/sca^BP2 flies have extra thoracic bristles.

(Lee et al., 1998)

sca^WB1/sca^OB7 Egfr^E3/Egfr^E1 double homozygotes have one R8 cell per ommatidium.

(Baker and Zitron, 1995)

Ommatidial clusters are irregularly spaced in mutant eye discs and contain variable numbers of cells, often more than in wild type. Mutant adults have rough eyes, with ommatidia having a variable number of photoreceptor cells, often more than in wild type.

(Baker et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101555

sca^OB7 / CyO

Notes on Origin

Discoverer

Comments

Mosaic analysis shows that sca⁺ has a function in the R8 cell.

(Baker et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sca^OB7

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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