FlyBase Allele Report: Dmel\snf[e8H]

General Information

Symbol

Dmel\snf^e8H

Species

D. melanogaster

Name

FlyBase ID

FBal0032746

Feature type

allele

Associated gene

Dmel\snf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Salz and Flickinger, 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: T97P. T97P falls within the highly conserved central domain of the protein, just outside of the N-terminal RRM.

(Salz and Flickinger, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:5,309,642..5,309,642 [+]

Nucleotide change:

A5309642C

Amino acid change:

T97P | snf-PA

Reported amino acid change:

T97P

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Salz and Flickinger, 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile | recessive

(Salz, 1992)

female sterile | dominant

(Salz, 1992)

Phenotype Manifest In

ovary

(Salz, 1992)

Detailed Description

Statement

Reference

Heterozygous females have ovarian tumours and are sterile. Homozygous females are fertile and have equal numbers if male and female progeny.

(Salz, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Sxl^f1, snf^e8H has lethal | dominant | female phenotype

(Albrecht and Salz, 1993)

Sxl^fP7B0, snf^e8H has lethal | dominant | female phenotype

(Albrecht and Salz, 1993)

Sxl^f1, snf^e8H has lethal | recessive | female | maternal effect phenotype

(Albrecht and Salz, 1993)

Sxl^fP7B0, snf^e8H has lethal | recessive | female | maternal effect phenotype

(Albrecht and Salz, 1993)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Displays a stronger female-lethal synergistic interaction with loss of function Sxl mutations (Sxl^f1 and Sxl^fP7B0) than snf^J210 (amorphic). Sxl^cF1.otu can suppress the interaction phenotype. One copy of P{SxlcF1} in wild type males, even under nonheat shock conditions, recovers only 2% of expected males. 67% of expected males are recovered from snf^e8H; P{SxlcF1} males.

(Salz and Flickinger, 1996)

Whereas female progeny heterozygous for Sxl^f9 from snf^e8H mothers are recovered less frequently than expected (65% relative viability), female progeny heterozygous for Sxl^fLS (defective in a later, maintenance/expression function) are fully viable.

(Albrecht and Salz, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

snf^e8H and snf¹ fail to complement each other and snf^JA2 partially complements snf^e8H and snf¹.

(Salz and Flickinger, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

snf^e8H

snf^e8h

(Burnette et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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